Results 51 to 60 of about 11,724,943 (303)
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
Entrevista com Dilséa Adeodata Bonetti
Serviço Social & Saúde, 2015 Refere-se à noite de 22 de setembro de 1977, quando a tropa de choque da Polícia Militar e agentes do Departamento de Ordem Política e Social (DOPS), sob o comando do coronel Erasmo Dias, na época Secretário de Segurança Pública de São Paulo, invadiram ...
Equipe Serviço Social & Saúde
doaj +1 more source
FEBS Letters, EarlyView.Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman +2 more
wiley +1 more source
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
Acknowledgement to Reviewers of Social Sciences in 2017
Social Sciences, 2018 Peer review is an essential part in the publication process, ensuring that Social Sciences maintains high quality standards for its published papers[...]
Social Sciences Editorial Office
doaj +1 more source
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions
FEBS Letters, EarlyView.We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva +10 more
wiley +1 more source
Human Service Organizations Management, Leadership & Governance, 2015 This article explores and describes social innovation, social intrapreneurship, and social entrepreneurship practiced by social workers within human service organizations. Each year, the nature and complexity of clients’ problems and challenges experienced by communities continuously evolves and grows.
Monica Nandan +2 more
openaire +2 more sources
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
Medicina, 2007 (10 de agosto de 2007) Por el cual se adopta el Plan Nacional de Salud Pública 2007-2010 El Presidente de la República de Colombia En uso de sus atribuciones constitucionales y legales, en especial las conferidas por el numeral 11 ...
Ministerio de Protección Social
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