Results 61 to 70 of about 436,469 (302)

The Concept of Gender Crossing in the Deirdre McCloskey’s Theory [PDF]

Journal of Interdisciplinary Sciences, 2018
This article explores the concept of gender identity of the famous American economist Deirdre McCloskey. The concept has three key elements: Firstly, gender identity does not directly refer to sexual orientation.
Khitruk Ekaterina
doaj  

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Socially Acceptable Behavior [PDF]

Queue, 2005
While perusing the ?popular? section of the social bookmarking site del.icio.us recently, I was struck by the myriad off-the-wall sites that users are bookmarking. Indeed, one of the most popular sites (311 bookmarks!) was titled, ?Vanishing Point: How to disappear in America without a trace.?
openaire   +2 more sources

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Acceptance of ELV Management: The Role of Social Influence, Knowledge, Attitude, Institutional Trust, and Health Issues

, 2022
The growth of Indonesia’s automotive sector has increased the number of end-of-life vehicles (ELVs), making ELV waste management a major issue. Most countries, such as Japan, China, and Europe, manage ELV waste well, but developing countries still ...
Rizqon Fajar, Edward Bantu, Karuhanga Samuel, Muhamad Razuhanafi Mat Yazid, Zambri Harun, Charli Sitinjak, Rosniza Aznie Che Rose, Zurinah Tahir, Rozmi Ismail, Wiyanti Fransisca Simanullang   +9 more
core   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

An exploratory trial of parental advice for increasing vegetable acceptance in infancy [PDF]

, 2015
Research suggests repeatedly offering infants a variety of vegetables during weaning increases vegetable intake and liking. The effect may extend to novel foods. The present study aimed to investigate the impact of advising parents to introduce a variety
Oliveira, A, Manios, Y, Beeken, R, Cooke, L, Moreira, P, Mavrogianni, C, Moschonis, G, Lopes, C, Fildes, AM, Wardle, J, Fildes, A, Moreira, Pedro   +11 more
core   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source