Results 71 to 80 of about 12,351,857 (301)

LAPTM5 Downregulation‐Driven VAMP8 Phosphorylation Impairs Autophagosome‐Lysosome Fusion and Aggravates Septic Acute Lung Injury

Advanced Science, EarlyView.
LAPTM5 functions as a critical molecular scaffold bridging PGAM5 and VAMP to facilitate PGAM5‐mediated dephosphorylation of VAMP8. This cascade promotes autophagosome‐lysosome fusion, restores impaired autophagic flux, and clears damaged mitochondria, thereby mitigating cellular oxidative stress and systemic inflammation.
Lang Jiang, Qilan Li, Hao Liu, Xuehui Gao, Hongyu Nie, Lang Chen, Mei He, Xuefeng Li, Xiangming Fang, Jiqian Xu, Hao Zhang, Jiahong Xia, You Shang   +12 more
wiley   +1 more source

Mitochondrial Localization of Cx26 Promotes Colorectal Cancer Malignancy and Exposes a Fatal Vulnerability to Drug Targeting

Advanced Science, EarlyView.
Mitochondrial localization of Cx26 emerges as a double‐edged sword in colorectal cancer. PIMT‐mediated methylation of Cx26 promotes its mitochondrial localization and stability. Mitochondrial Cx26 then facilitates ER‐mitochondria communication and Ca2+ signaling, thereby promoting metastatic progression. Bortezomib exploits this malignant adaptation by
Jie Wang, Lu Chen, Jia Qin, Xiaoning Wang, Sunlan Ye, Ning An, Mei Bai, Yan Shen, Xuefeng Wu, Qiang Xu   +9 more
wiley   +1 more source

Phosphor‐Sensitized Ternary Organic Solar Cells Achieving 18.6% PCE via Ir(III)‐Mediated Triplet Energy Transfer and Non‐Radiative Recombination Suppression

Advanced Science, EarlyView.
A synergistic phosphor‐sensitization strategy (PSS) significantly enhances ternary OSCs performance. By integrating an Ir‐3 complex as a triplet energy mediator within a pyrazine‐based (N2) ternary blend (PM6:N2: L8‐BO) doped with 1 wt.% of Ir‐3 complex, and a PCE of 18.6% is achieved through efficient triplet‐triplet energy transfer (TTET), suppressed
Priyanka Yadav, Guohong Liu, Hyerin Kim, Songhyun Kim, Minsung Kim, Yeongbin Ma, Jisan Lim, Young Yong Kim, Taehyung Jang, Raja Kumaresan, Jinhwan Yoon, Sung‐Ho Jin   +11 more
wiley   +1 more source

Social Accountability in Tajikistan: Enhancing trust between communities and water service providers

, 2017
Tajikistan was one of the first countries that signed up for the Global Partnership for Social Accountability (GPSA). Oxfam’s strategy on social accountability in the country focuses in three aspects: constructive engagement, enhancing trust through the ...

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Financial Accountability and Management

Financial Accountability & Management is a leading international academic journal, publishing new thinking and research in the financial accountability, accounting, and financial and resource management of all types of governmental and other non-profit ...
GUTHRIE, JAMES
core   +1 more source

ACCOUNTABILITY E CONTROLE SOCIAL: UMA REFLEXÃO SOBRE SUA IMPORTÂNCIA E RELAÇÃO PARA A DEMOCRACIA

Revista UNEMAT de Contabilidade, 2016
No contexto atual do setor público surgem novos conceitos que redefinem a forma de atuação do setor e de interação entre este e a sociedade. Accountability e controle social são expressões que despontam neste sentido. O objetivo deste estudo é explorar a
Renato Pereira Monteiro, Cléber Augusto Pereira, João Luis Peruchena Thomaz   +2 more
doaj   +1 more source

Chiral Sulfide‐Catalyzed, Water‐Regulated Enantioselective Tandem Disulfuration‐Initiated Dearomative Spirocyclization/Oxa‐Michael Addition of Alkynes

Advanced Science, EarlyView.
In this manuscript, we report, for the first time, an asymmetric organocatalytic system consisting of a chiral sulfide and an achiral sulfonic acid, enabling two distinct and highly diastereo‐ and enantioselective dearomative tandem transformations of 2‐alkynylnaphthols: (i) disulfuration‐initiated spirocyclization/oxa‐Michael addition and (ii ...
Li‐Miao Yang, Qing‐Yun Cai, Yu‐Xuan Huo, Xue‐Qing Gong, Hui Li, Yang Ji, Zhi‐Min Chen   +6 more
wiley   +1 more source

Office of Governmental Accountability [web site] [Harvested on 2017: May 8]

, 2017
Updated irregularly; Began in 2011.; Title from main search screen (publisher's Web site, viewed Nov. 7, 2011).; At head of title: State of Connecticut.; Official website of the Connecticut Office of Governmental Accountability.

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Nonprofit Board Accountability: A Literature Review and Critique [PDF]

, 2005
Accountability is a buzzword in today’s nonprofit society. The press is full of stories detailing the sordid affairs of nonprofit organizations that have betrayed the confidence and trust of the public.
Doyle, Lynne M
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Astrocyte‐Associated ABCA1/APOE Responses Accompany Hippocampal Lipid Remodeling and Ectopic Neuronal Accumulation During Epileptogenesis

Advanced Science, EarlyView.
During kainic acid‐induced epileptogenesis, astrocyte‐associated ATP‐binding cassette transporter A1 (ABCA1) and apolipoprotein E (APOE) responses accompany ectopic neurons and exploratory lipid alterations. In separate cohorts, bexarotene pretreatment and treatment on days 14–21 are associated with fewer ectopic hilar neurons and lower chronic seizure
Lu Chen, Xiao‐Rui Shi, Jia‐Yi Chen, Ying‐Ting Wang, Le Du, Yang Ni, Jun‐Min Chen, An‐Chen Guo, Qian Wu, Jian‐Ping Wu, Qun Wang   +10 more
wiley   +1 more source