Results 41 to 50 of about 39,150 (279)

Harnessing the temporal and projective attributes of human agency to promote anticipatory climate change adaptation [PDF]

, 2022
Human agency is seen as a critical component of adaptive capacity concerning environmental change. This capacity may entail social actor's ability to learn from past experience, and create opportunities in the present for dealing with uncertainty and ...
Mackey, Brendan, Darryl Low Choy, Kerrylee Rogers, Pazit Taygfeld, Brendan Mackey, Low Choy, Darryl, Asbridge, Emma F., Taygfeld, Pazit, Asbridge, Emma F, Emma F. Asbridge, Choy, Darryl Low, Rogers, Kerrylee, Serrao-Neumann, Silvia, Silvia Serrao‐Neumann   +13 more
core   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Multi-level governance in federal contexts: the Social Assistance Policy in the City of São Paulo

Brazilian Political Science Review, 2017
This article examines the governance of social assistance in the City of São Paulo by considering the interplay between the federal normative acts that conform to the Unified System of Social Assistance (SUAS) and the decisions taken at the municipal ...
Renata Bichir, Gabriela Horesh Brettas, Pamella Canato   +2 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Tragic Stability and Elusive Selfhood: On the Drive for Self-Development in Contemporary China

Journal of Current Chinese Affairs, 2021
The requirement for “self-development” through the ceaseless acquisition of skills and credentials has long been central for young adults in China. However, due to the multiple and unpredictable demands of social institutions, many social actors also ...
Gil Hizi
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Whose vulnerability? Inverting constructions of older people as a vulnerable group during the coronavirus pandemic in Ireland

SSM: Qualitative Research in Health
This Grounded Theory study analyses social constructions of older people and their care in the official discourses around the Irish government's response to the Covid-19 pandemic.
Katharine Schulmann, Virpi Timonen, Catherine Conlon   +2 more
doaj   +1 more source

Categories of ‘Political Actor’ and ‘Political Agency’ as Research Objects of Polish Political Theorists

Teoria Polityki, 2023
The aim of the article is to present the history of research on the categories of “political actor” and “political agency” conducted by Polish political scientists.
Piotr Borowiec
doaj   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Exploring social processes in transformation: the case of a collaborative water partnership in South Africa

Ecosystems and People, 2023
We explore the social processes supporting transformation towards collaborative water governance in the uMngeni catchment, South Africa. Using Holling’s adaptive cycle as a heuristic of phases (conservation, release, reorganisation and exploitation ...
Catherine B. Pringle, Richard Meissner, Reinette Biggs, Claudia Pahl-Wostl, Sabine Stuart-Hill, Nadia Sitas   +5 more
doaj   +1 more source