Results 61 to 70 of about 39,150 (279)
FEBS Letters, EarlyView.Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley +1 more source
Médialab stories: How to align actor network theory and digital methods
Big Data & Society, 2018 The history of laboratories may become controversial in social sciences. In this paper, the story of Sciences Po Médialab told by Venturini et al.
Dominique Boullier
doaj +1 more source
Un concepto de actor para la ciencia política [PDF]
, 2006 The concept of actor is widely employed in social sciences as well as in politicians and journalists’ discourse. That is why it is so striking the lack of definitions.
García Sánchez, Esther +1 more
core
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Cahiers de la Recherche sur l'Education et les Savoirs, 2018 This article demonstrates how Guinean teachers, facing difficult working and living conditions, develop strategies in order to improve their situation.
Ester Botta Somparé +1 more
doaj +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
European CountrysideRural digitalisation is often approached from a structural research perspective, focusing on broadband infrastructure and socio-economic contextual conditions.
Mettenberger Tobias +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Designing the past: the National Trust as a social-material agency
, 2009 The National Trust was founded in 1895 for ‘the preservation of places of historic interest or natural beauty’. While the distinction between the cultural and the natural seemed obvious at that time and members and visitors were not even implicated ...
Wallace, Stephen +2 more
core
Molecular Oncology, EarlyView.Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano +6 more
wiley +1 more source