Results 81 to 90 of about 39,150 (279)
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
L’engagement et la responsabilité des interprètes en milieu social : les limitations de leur pouvoir
Studia Romanica Posnaniensia, 2019 This paper discusses the agency of community interpreters in a cross-cultural environment. Their empowerment is determined by several linguistic and extralinguistic factors, such as: mastering the language of communication by the speakers, social status
Iwona Kasperska
doaj
Political Agency at the Digital Crossroads?
Media and Communication, 2016 This thematic issue presents the outcome of the 2015 ECREA Communication and Democracy Section Conference “Political Agency in the Digital Age” that was held at the Copenhagen Business School in Denmark.
Anne Kaun, Maria Kyriakidou, Julie Uldam
doaj +1 more source
Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source
Colloquia Germanica StetinensiaIn the context of global changes, the article explores the creation of a community of humans with nonhuman actors in Franz Hohler’s short story "Die Rückeroberung" (1982), while questioning the anthropocentric perspective.
Natalia Czudek
doaj +1 more source
Performing and accounting language and identity : Agency as actors-in-(inter)action-with-tools
, 2014 A sociocultural perspective on communication and development recognizes that artifacts and cultural tools, including language, the most significant of tools, (Lantolf, 2000; Perret-Clermont, 2009; Vygotsky, 1962) are in a mediational symbiotic ...
Bagga-Gupta, Sangeeta,
core
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
The speaking body: Metaphor and the expression of extraordinary experience
Temenos, 2016 This article explores the relationship between language, experience, and the body. Employing a phenomenological approach that takes the sensory body as its starting point, it focuses on three instances of ‘divine experience’, looking at the ways in which
Jamie Barnes
doaj +1 more source
Migrant workers and labour agency: social actors or submissive players?
, 2021 Migrant workers tend to cluster in particular industries, occupations and geographical areas and to experience disadvantageous working conditions. This article discusses the role of migrants as social actors in the labour market by looking at how and to what extent they are able to actually influence the conditions of their working lives.
openaire +1 more source
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source