Results 91 to 100 of about 39,150 (279)
The interplay of agencies in institutional disruption: An explanation of the slow death of asbestos in France [PDF]
Although central to many debates in neo-institutional theories, the concept of agency still remains fairly ambiguous and sometimes elusive. In particular, the agency concept tends to conflate two different phenomena, the power of agency (the capacity to ...
Hélène Peton, Antoine Blanc
core
Rights based approaches to addressing food poverty and food insecurity in Ireland and UK [PDF]
, 2012 Food poverty is an important contributing factor to health inequalities in industrialized countries; it refers to the inability to acquire or eat an adequate quality or sufficient quantity of food in socially acceptable ways (or the uncertainty of ...
O'Connor, Deirdre +3 more
core +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Nepal’s Status‐Seeking Endeavors: Between Normative Convergence and Geopolitical Interests
Politics and GovernanceDue to limited material and geopolitical factors, the agency of small states is limited in international politics. As such, these states may seek to mitigate such weaknesses through status-seeking, adopting peculiar foreign policy approaches or ...
Bibek Chand
doaj +1 more source
Migration systems, pioneers and the role of agency [PDF]
The notion of a migration system is often invoked but it is rarely clearly defined or conceptualized. De Haas has recently provided a powerful critique of the current literature highlighting some important flaws that recur through it.
Hein de Haas +2 more
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Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
The sociological study of nurse-physician professional relationship in Iran
Iranian Journal of Nursing and Midwifery Research, 2016 Background: During recent decades, various factors have modified the nurse–physician professional relationship pattern in hospital settings. The present study investigates the typology and dynamics of this relationship as well as the effects of social ...
Maryam Mehrabi +2 more
doaj +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Return migration as an engine of social change?: Reverse diasporas' capital investments at home
, 2015 This chapter explores the resources, or forms of capital, that returnees bring back to their home-countries, and the ways in which they generate economic and social change through local investments by means of entrepreneurial activity.
Schnetzinger, Heidi
core +1 more source