Results 71 to 80 of about 39,150 (279)

S’appuyer sur les théories et concepts du capital social pour interpréter une politique locale de développement économique : le cas du Grand Halifax, Canada

Revue Interventions Économiques, 2016
Can a public-private economic development agency implement a strategy based on social capital? This paper proposes to look at some of the key answers.
Clément Marinos
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Struggles for Life: Smallholder Farmers’ Resistance and State Land Relations in Contemporary Cambodia

Journal of Current Southeast Asian Affairs, 2019
Struggles revolving around questions of land access and control occupy a central place in the political and social life of contemporary Cambodia. In this study, we examine three cases of struggles against economic [State] land concessions.
Jean-Christophe Diepart, Chanrith Ngin, Il Oeur   +2 more
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Youth - Actor of Social Change. Theoretical reflections on young people's agency in comparative perspective. Interim discussion paper for the UP2YOUTH project

, 2007
This working paper covers the interim results of the European research project "UP2YOUTH - Youth as actor of social change?". UP2YOUTH was funded within the European Union's 6th framework programme as a coordinated action network from 2006 to 2009. The network consisted of 18 research institutes from 15 EU countries.
Pohl, Axel, Stauber, Barbara, Walther, Andreas   +2 more
openaire   +1 more source

Institutional Actors, Learning and Agency

, 2010
This article argues that conventional approaches to infrastructure reform in developing countries underestimate the agency of local actors and organisations in assisting small and medium-scale enterprises (SMEs) to surmount problems.
Nausheen H. Anwar
core   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

'Mysterious in content' : the European Union peacebuilding framework and local spaces of agency in Bosnia-Herzegovina

, 2012
This thesis aims to investigate EU peacebuilding in Bosnia-Herzegovina, focusing on the ways in which EU actors engage with local cultural actors and vice versa.
Kappler, Stefanie
core