Results 91 to 100 of about 37,462 (252)

Perceived Stress and Burden of Care in Elderly Caregivers: The Moderating Role of Resilience

Sālmand, 2022
Objectives This study aimed to investigate the moderating role of resilience in the association between perceived stress and the burden of care among elderly caregivers at nursing homes in Tehran in 2016.
Mahsa Jafari, Fardin Alipour, Ghoncheh Raheb, Mostafa Mardani   +3 more
doaj  

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Behavioral and Social Sciences and Public Health at CDC [PDF]

Although the History of CDC spans 60 years, only during the last 2 decades of the 20th century did the agency come to recognize and better understand the importance of the behavioral and social sciences to its overall mission.

core  

Üniversite eğitim öğretiminde sosyal ağ analizi [PDF]

, 2019
Sosyal ağ analizi, modern yazılımlar sayesinde bireylerin ilişkilerini sayısallaştırarak bu ilişkilerin boyutlarına dair bilimsel veriler sunmaktadır. Sosyal ağlar, günümüzde öğrenme öğretme alanında da yaygınlaşmıştır.
Aytekin, Alper, Ayaz, Ahmet, Tüminçin, Fatma, Aktaş, Gülşah   +3 more
core  

Artificial Intelligence in Aviation: A Path Analysis

Journal of Aviation/Aerospace Education & Research
The study applied the Technology Acceptance Model (TAM) to assess trust in artificial intelligence (AI) within the US commercial aviation industry.
Leila Halawi, Mark D Miller, Sam J Holley   +2 more
doaj   +1 more source

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

Molecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen, Jiancheng Cheng, Ruili Hou, Xiaoyuan Zheng, Li Su, Maria Moksnes Bjaanæs, Anna Karlsson, Maria Planck, Johan Staaf, Åslaug Helland, Manel Esteller, David C. Christiani, Feng Chen, Xiaofei Cao, Ruyang Zhang   +14 more
wiley   +1 more source

Structural barriers to sexual and reproductive health care among Black and Latina cisgender and transgender U.S. women who use drugs: a qualitative study

BMC Health Services Research
Background Black and Latina women and women who use drugs in the United States (U.S.) face multilevel barriers to receiving sexual and reproductive health (SRH) care that meets their needs.
Madina Agénor, Aisha Tipnis, Mikaela Byers, Tori Davis, Madeline Noh, Reagan Dunham, Kelly Reyna, Queen Adesuyi, Angela R. Bazzi, Katie B. Biello   +9 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source