Results 111 to 120 of about 1,578,319 (310)

Effective education and communication strategies to promote environmental engagement : The role of social-psychological mechanisms [PDF]

, 2016
Communicators of climate change seek ways to better educate and motivate individuals to personally commit to sustainable, energy-saving activities. However, critical psychological and social barriers to conservation make this task challenging. Behavioral
Cornwell, Francis James, UNESCO, Zaval, Lisa   +2 more
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Structural barriers to sexual and reproductive health care among Black and Latina cisgender and transgender U.S. women who use drugs: a qualitative study

BMC Health Services Research
Background Black and Latina women and women who use drugs in the United States (U.S.) face multilevel barriers to receiving sexual and reproductive health (SRH) care that meets their needs.
Madina Agénor, Aisha Tipnis, Mikaela Byers, Tori Davis, Madeline Noh, Reagan Dunham, Kelly Reyna, Queen Adesuyi, Angela R. Bazzi, Katie B. Biello   +9 more
doaj   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Harnessing the power of patient videos to enhance social and behavioral sciences education

MedEdPublish, 2016
It has become increasingly important to address the challenge of incorporating social and behavioral sciences (SBS) into medical curricula. This commentary describes how the use of patient videos can be used to overcome barriers in teaching of SBS in non-
Shannon Nanna, Sean Tackett, Shiv Gaglani   +2 more
doaj  

Against Game Theory [PDF]

, 2015
People make choices. Often, the outcome depends on choices other people make. What mental steps do people go through when making such choices? Game theory, the most influential model of choice in economics and the social sciences, offers an answer, one ...
Lucas, Gale M., McCubbins, Mathew D., Turner, Mark   +2 more
core   +2 more sources

NKCC1: A key regulator of glioblastoma progression

Molecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen, Diana Freitag, Madlen Haase, Christian Senft, Falko Schwarz, Silke Keiner   +5 more
wiley   +1 more source

The role of personal therapy on university adaptation, psychological resilience and life satisfaction

Ψυχολογία: το Περιοδικό της Ελληνικής Ψυχολογικής Εταιρείας
The transition to university presents several challenges for emerging adults, with the literature revealing an association between university adaptation, life satisfaction and psychological resilience.
Panagiotis Parpottas, Malvina Antonioudaki, Paris Vogazianos   +2 more
doaj   +1 more source

Future of Capitalism [PDF]

, 2011
The moral foundation of capitalism should be reconsidered. Modern capitalism is disembedded from the social and cultural norms of society and produced a deep financial, ecological and social crisis. Competitiveness is the prevailing ideology of today’s
Zsolnai, László
core  

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source