Results 61 to 70 of about 2,967,604 (309)
Molecular Oncology, EarlyView.Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu +11 more
wiley +1 more source
Sensing and Modeling Human Behavior Using Social Media and Mobile Data [PDF]
arXiv, 2017 In the past years we have witnessed the emergence of the new discipline of computational social science, which promotes a new data-driven and computation-based approach to social sciences. In this article we discuss how the availability of new technologies such as online social media and mobile smartphones has allowed researchers to passively collect ...
arxiv
Molecular Oncology, EarlyView.This article advocates integrating temporal dynamics into cancer research. Rather than relying on static snapshots, researchers should increasingly consider adopting dynamic methods—such as live imaging, temporal omics, and liquid biopsies—to track how tumors evolve over time.
Gautier Follain +3 more
wiley +1 more source
Molecular Oncology, EarlyView.This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani +14 more
wiley +1 more source
BMC Health Services Research, 2019 Background Most seniors wish to live independently for as long as possible. Gerontechnologies such as personal alarms or remote control systems, have the potential to help them age in place.
Marc Haufe +2 more
doaj +1 more source
Yourfeed: Towards open science and interoperable systems for social media [PDF]
arXiv, 2022 Existing social media platforms (SMPs) make it incredibly difficult for researchers to conduct studies on social media, which in turn has created a knowledge gap between academia and industry about the effects of platform design on user behavior. To close the gap, we introduce Yourfeed, a research tool for conducting ecologically valid social media ...
arxiv
Molecular Oncology, EarlyView.This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu +12 more
wiley +1 more source
arXiv, 2016 Social influence plays an important role in human behavior and decisions. The sources of influence can be generally divided into external, which are independent of social context, or as originating from peers, such as family and friends. An important question is how to disentangle the social contagion by peers from external influences.
arxiv
Theory In, Theory Out: The uses of social theory in machine learning for social science [PDF]
arXiv, 2020 Research at the intersection of machine learning and the social sciences has provided critical new insights into social behavior. At the same time, a variety of critiques have been raised ranging from technical issues with the data used and features constructed, problematic assumptions built into models, their limited interpretability, and their ...
arxiv
Loss of proton‐sensing GPR4 reduces tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.G protein‐coupled receptor 4 (GPR4) is a pH‐sensing receptor activated by acidic pH. GPR4 expression is increased in patients with inflammatory bowel disease who are at high risk of developing colorectal cancer. In mouse models, loss of GPR4 attenuated tumor progression. This correlated with increased IL2 and natural killer cell activity.
Leonie Perren +16 more
wiley +1 more source