Results 81 to 90 of about 1,495,220 (334)

Increasing appropriate social communication and pragmatic language skills in young adults with autism spectrum disorders [PDF]

open access: yes, 2016
This report seeks to explore intervention methodologies that can be adapted for use with young transitional adults with Autism Spectrum Disorders (ASD) to increase appropriate social communication.
Coppock, Amanda Rene'
core   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

open access: yesFEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva   +10 more
wiley   +1 more source

Implementing LGBTQ-affirmative CBT: study protocol for an effectiveness-implementation trial at 90 LGBTQ community centers

open access: yesBMC Health Services Research
Background Sexual and gender minorities (SGM) experience among the largest mental health disparities of any population. One driver has been the lack of evidence-based practices (EBPs) addressing the distinct mechanisms underlying SGM’s risk.
John E. Pachankis   +20 more
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Project ESTEEM protocol: a randomized controlled trial of an LGBTQ-affirmative treatment for young adult sexual minority men’s mental and sexual health

open access: yesBMC Public Health, 2019
Background Young gay and bisexual men disproportionately experience depression, anxiety, and substance use problems and are among the highest risk group for HIV infection in the U.S.
John E. Pachankis   +12 more
doaj   +1 more source

(WP 2017-04) Behavioral Economics and the Positive-Normative Distinction: Sunstein’s \u3cem\u3eChoosing Not to Choose\u3c/em\u3e and Behavioral Economics Imperialism [PDF]

open access: yes, 2017
This paper examines behavioral economics’ use of the positive-normative distinction in its critique of standard rational choice theory as normative, and argues that it departs from Robbins’ understanding of that distinction in ways that suggest ...
Davis, John B.
core   +1 more source

Cell density–dependent nuclear‐cytoplasmic shuttling of SETDB1 integrates with Hippo signaling to regulate YAP1‐mediated transcription

open access: yesFEBS Letters, EarlyView.
At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom   +3 more
wiley   +1 more source

Translating Social Science Concepts into Medical Education: A Model and a Curriculum [PDF]

open access: yes, 2014
Most serious efforts aimed at linking social and behavioral sciences knowledge tomedical practice have included models which integrate social and behavioral scienceconcepts.
Begun, James W., Rieker, Patricia P.
core   +1 more source

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