Results 51 to 60 of about 181,223 (266)

In vitro properties of patient serum predict clinical outcome after high dose rate brachytherapy of hepatocellular carcinoma

Molecular Oncology, EarlyView.
Following high dose rate brachytherapy (HDR‐BT) for hepatocellular carcinoma (HCC), patients were classified as responders and nonresponders. Post‐therapy serum induced increased BrdU incorporation and Cyclin E expression of Huh7 and HepG2 cells in nonresponders, but decreased levels in responders.
Lukas Salvermoser, Jan Niklas Schäfer, Shraga Nahum Goldberg, Philipp Maximilian Kazmierczak, Moritz Nikolaus Gröper, Philipp Franz Linden, Elif Öcal, Tanja Burkard, Stefanie Corradini, Najib Ben Khaled, Moritz Wildgruber, Max Seidensticker, Jens Ricke, Matthias Stechele, Marianna Alunni‐Fabbroni   +14 more
wiley   +1 more source

Children’s screen time and psychosocial symptoms at 5 years of age – the role of parental factors

BMC Pediatrics
Background and objectives Electronic media (e-media) has become a universal part of young children’s daily lives. Previous studies have found an association between increased screen time and children’s psychosocial symptoms.
Janette Niiranen, Olli Kiviruusu, Riitta Vornanen, Anneli Kylliäinen, Outi Saarenpää-Heikkilä, E. Juulia Paavonen   +5 more
doaj   +1 more source

Oral Problems and Psychological Status of Older Adults Referred to Hospital and Its Relationship With Cognition Status, Stress, Anxiety, and Depression

علوم بهداشتی ایران, 2022
Background and Purpose: Oral health is a critical factor in the quality of life (QoL) of older adults in relation to their nutrition, mental health, and healthy social relationships.
Shahab Papi, Seyed Vahid Hosseini, Farzaneh Bahadori, Vahideh Rezapour, Amir Mohamad Moghadasi, Reza FadayeVatan   +5 more
doaj  

Hypertensive disorders of pregnancy among women of migrant origin in Finland: A population‐based study

Acta Obstetricia et Gynecologica Scandinavica, 2022
Introduction Hypertensive disorders of pregnancy are a leading cause of maternal and perinatal mortality and morbidity worldwide. We studied the prevalence of hypertensive disorders of pregnancy among women of migrant origin in Finland.
Kalpana Bastola, Päivikki Koponen, Natalia Skogberg, Mika Gissler, Tarja I. Kinnunen   +4 more
doaj   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Integrated serological surveillance of communicable diseases in the Paraguayan Chaco, 2019

Revista Panamericana de Salud Pública
Objective. To establish baseline seroprevalence of soil-borne, waterborne, and foodborne diseases and to monitor diseases that are eliminated or on the path to elimination in the Paraguayan Chaco. Methods. A total of 1 100 school-age children (6–15 years)
Patricia Galeano, Claudia Huber, Violeta Ortiz, Soraya Araya, Vilma Teresa Pérez, Guillermo Sequera, María Paz Ade, Gloria Rey-Benito, Pamela Bravo, Ana Luciañez, Romeo Montoya, Silvia Giselle Ibarra-Ozcariz, Viviana De Egea, Águeda Cabello, Ana Morice, Martha Idalí Saboyá-Díaz, E. Brook Goodhew, Gretchen Cooley, Diana Martin   +18 more
doaj   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

The effects of the changes in the depression on suicidal ideation among older adults aged 75 and above before and after the COVID-19

BMC Geriatrics
Background The unprecedented pandemic situation of COVID-19 has had a negative impact on the mental health of many people, especially among the "old-old" older adults who are aged 75 or older.
Kyu-Hyoung Jeong, Sunghwan Cho, Yeon Jae Hwang, Dayoon Park, Seoyoon Lee   +4 more
doaj   +1 more source