Results 111 to 120 of about 20,143,172 (287)

Implementing agents for a collaborative online learning environment

Journal of Computer Science and Technology, 2004
This paper discusses the main lines used to model intelligent agents that will operate in a Collaborative Online Learning Environment-COLE. The aim of COLE is to evaluate the contribution that Information Technology and Multiagent Systems can bring to ...
Hilton José Silva de Azevedo, Edson Emílio Scalabrin, Marcio de Paula Faria, Fairus Manfroi   +3 more
doaj  

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Contextual Annotation Framework using Ontology-Based Contextual Annotation Service [PDF]

, 2008
Current systems do not provide a context when sharing and reusing annotations. This research investigated how this may be achieved. This thesis provides an overview of the work that has been undertaken in the fields of Semantic Web, adaptive hypermedia ...
Maneewatthana, Thanyalak
core   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

A Comprehensive Review of Facial Beauty Prediction Using Multi-task Learning and Facial Attributes

ARO-The Scientific Journal of Koya University
Beauty multi-task prediction from facial attributes is a multidisciplinary challenge at the intersection of computer vision, machine learning, and psychology.
Ali H. Ibrahem, Adnan M. Abdulazeez
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Road use as conversation: a Multimodal Multi-scale Coordinated Action Model (MCAM) for immersive and generative traffic safety applications

Frontiers in Computer Science
Understanding how VRUs—pedestrians, cyclists, and micromobility users—coordinate social action and resolve conflict in mixed-mode urban traffic is not merely a technological but a fundamental human factors problem.
Merve Keskin, Rebekah Wegener, Martin Karl Moser   +2 more
doaj   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

Bangla-ToCo: A context-aware dataset for Bengali toxic comment detectionMendeley Data

Data in Brief
In today’s online world, abusive and toxic comments on social media have become a growing concern, particularly for languages like Bengali, where there are currently few reliable automatic moderation systems.
Sayma Akter Rupa, Md. Musfique Anwar, Nadia Afrin Ritu, Khandoker Nosiba Arifin   +3 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source