Results 151 to 160 of about 20,143,172 (287)

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

ValuesML: A new multilingual dataset for values detection in news and political manifestos. [PDF]

Behav Res Methods
Scharfbillig M, Reitis-Münstermann T, Stefanovitch N, Kiesel J, Brock PS, Sneddon J, Cartier E, Ardag M, Arieli S, Daniel E, Dobewall H, Karl J, Krasteva A, Oeschger TP, Petasis G, Russo L, Seddone A, Tamo-Larrieux A, van Herk H, Avcı N, Bobba G, Chiron P, Çoymak A, Dagioglou M, Katsamori D, Leijen I, Öney B, Scholz-Kuhn R, Zankina E, Astor S, Auer P, Aulino L, Bardi A, Battaglia F, Beierlein C, Benish-Weisman M, Christodoulou C, Collins PR, Coppola I, Dâmaso M, Morren M, Elizarov E, Erlich N, Ezeigwe-Ephraim P, Fischer R, Gaeta MC, Gatt L, Gerera N, Goldman S, Gonthier F, Habermann S, Hristova M, Yapali DI, Izzo L, Kapetanakis P, Kışlıoğlu R, Koleva C, Koleva R, Lake J, Mesplou M, Ninova V, Önal ES, Oppenheim-Weller S, Ozturk D, Paparrigopoulos IE, Ponizovskiy V, Reeskens T, Romano MF, Schalk T, Starovolsky-Shitrit A, Smallenbroek O, Topuz Ö, Vauclair CM, Di Vetta G, Ye S.   +74 more
europepmc   +1 more source

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

FEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose, Kotaro Ozaki, Ryohei Kuriyama, Yuka Ikemoto, Kazuhiro Mio, Yuji C. Sasaki, Tatsuya Arai, Sakae Tsuda, Yoichi Shinkai, Masahiro Kuramochi   +9 more
wiley   +1 more source

A Consensus Genome Sequence for the Social Amoeba Dictyostelium giganteum. [PDF]

Genome Biol Evol
Sharma A, Khushi K, Ravindran F, Kadandale JS, Choudhary B, Srinivasan S, Nanjundiah V.   +6 more
europepmc   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Digital technologies for non-invasive stress detection, monitoring, and mitigation in children and adolescents: a scoping review. [PDF]

Front Digit Health
Nasser A, Baslyman M, Elferik S.
europepmc   +1 more source

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

FEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell, Cassy Ross, Panagiota S. Filippou, Bruno Silvester Lopes, Dominic Gilchrist, Paul Dean, Kamar Ameen‐Ali, Tora K. Smulders‐Srinivasan, Ahmad A. Khundakar   +8 more
wiley   +1 more source

Natural language processing-driven knowledge graphs for transformative public health intelligence and research datasets in urgent and emergency care. [PDF]

Front Public Health
Humphries C, Anand A, Casey A, Chapman W, Harrison K, Hillis JM, James E, MacIntyre DJ, Nicholson K, Schölin L, Taylor RA, Tomlinson C, Robertson D.   +12 more
europepmc   +1 more source

Ionomycin suppresses cancer cell growth by disrupting mitochondrial transcription

FEBS Open Bio, EarlyView.
In this study, we identify a new function for the selective Ca2+ ionophore, ionomycin, as an inhibitor of mitochondrial transcription. Both total and nascent RNA analyses revealed that ionomycin treatment reduces the transcription of mitochondrial genes.
Lishen Wang, Mingqiang Deng, Dongmei He, Diqin Lai, Dongjun Liu, Dengyong Zhu, Zhenhua Zhang, Peng Tang, Chuanman Zhou, Menghui Yin, Xichen Bao   +10 more
wiley   +1 more source