The Integration of Child Tax Credits and Welfare: Evidence from the National Child Benefit Program [PDF]
In 1998, the Canadian government introduced a new child tax credit. The innovation in the program was its integration with social assistance (welfare).
Kevin Milligan, Mark Stabile
core
Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
The Influence of Family-Based Social Assistance Programs and Parenting on Child Development: A Conceptual Framework for Research with U.S. Families in Poverty. [PDF]
J Fam Theory RevOsborne KR.
europepmc +1 more source
Strengthening governance of social safety nets in East Asia [PDF]
Several East Asian countries, in the aftermath of the global financial crisis, are considering an expansion of their social safety net programs. In many cases, existing delivery mechanisms for social assistance in the region tend to be basic, in line ...
Giannozzi, Sara, Khan, Asmeen
core
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
Moving on income as a social determinant of health: free transit for social assistance recipients in Kingston, Ontario. [PDF]
Can J Public HealthHolland MR +3 more
europepmc +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Survival analysis of Chagas disease patients, beneficiaries of social security and social assistance in Brazil, 1942-2016. [PDF]
Rev Bras EpidemiolLimongi JE +5 more
europepmc +1 more source
Harnessing employment-based social assistance programmes to scale up nature-based climate action. [PDF]
Philos Trans R Soc Lond B Biol Sci, 2020 Norton A +5 more
europepmc +1 more source