Results 251 to 260 of about 5,203,222 (297)

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Long‐Term Follow‐Up of Chemotherapy‐Associated Biological Aging in Women With Early Breast Cancer

Aging and Cancer, EarlyView.
Women threated with adjuvant chemotherapy for early breast cancer have sustained long‐term increase in p16INK4a,, a robust marker of cell senescence, suggesting a chemotherapy‐associated age acceleration. p16INK4a as well as other biomarkers may identify patients at greatest risk for senescence‐related diseases of aging.
Hyman B. Muss, Alexis C. Wardell, Allison M. Deal, Kirsten A. Nyrop, Allison Ross, Yara G. Abdou, Jeffrey D. Aldrich, Lisa A. Cary, E. Claire Dees, Katherine E. Reeder‐Hayes, Emily M. Ray, Natalia Mitin, Denis Tsygankov   +12 more
wiley   +1 more source

Prognostic Implications of Sleep Architecture for Patients Admitted to the Intensive Care Unit With Status Epilepticus

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Status epilepticus (SE) is associated with significant mortality. Sleep architecture may reflect normal brain function. Impaired sleep architecture is associated with poorer outcomes in numerous conditions. Here we investigate the association of sleep architecture in continuous EEG (cEEG) with survival in SE.
Ran R. Liu, Marcus C. Ng, Gavin P. Winston, Sabrina Schaly, Garima Shukla, Lysa Boissé Lomax   +5 more
wiley   +1 more source

Remote Monitoring in Myasthenia Gravis: Exploring Symptom Variability

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Myasthenia gravis (MG) is a rare, autoimmune disorder characterized by fluctuating muscle weakness and potential life‐threatening crises. While continuous specialized care is essential, access barriers often delay timely interventions. To address this, we developed MyaLink, a telemedical platform for MG patients.
Maike Stein, Maximilian Mönch, Meret Herdick, Frauke Stascheit, Sarah Hoffmann, Hannah Preßler, Philipp Mergenthaler, Carla Dusemund, Paolo Doksani, Haoqi Sun, Pushpa Narayanaswami, Andreas Meisel, Lea Gerischer, Sophie Lehnerer   +13 more
wiley   +1 more source

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Early Social Attention Impairments in Autism: Social Orienting, Joint Attention, and Attention to Distress.

Developmental Psychology, 2004
This study investigated social attention impairments in autism (social orienting, joint attention, and attention to another's distress) and their relations to language ability. Three- to four-year-old children with autism spectrum disorder (ASD; n = 72), 3- to 4-year-old developmentally delayed children (n = 34), and 12- to 46-month-old typically ...
Geraldine Dawson, Karen Toth, Robert Abbott, Julie Osterling, Jeff Munson, Annette Estes, Jane Liaw   +6 more
openaire   +2 more sources

Attentive Recurrent Social Recommendation

The 41st International ACM SIGIR Conference on Research & Development in Information Retrieval, 2018
Collaborative filtering(CF) is one of the most popular techniques for building recommender systems. To alleviate the data sparsity issue in CF, social recommendation has emerged by leveraging social influence among users for better recommendation performance.
Peijie Sun, Le Wu, Meng Wang 0001
openaire   +1 more source

Human social attention

2009
The present chapter suggests that while there is strong evidence that specific brain systems are preferentially biased toward processing gaze information, this specificity is not mirrored by the behavioral data as measured in highly controlled impoverished model tasks.
Birmingham, Elina, Kingstone, Alan
openaire   +3 more sources

Timeline generation with social attention

Proceedings of the 36th international ACM SIGIR conference on Research and development in information retrieval, 2013
Timeline generation is an important research task which can help users to have a quick understanding of the overall evolution of any given topic. It thus attracts much attention from research communities in recent years. Nevertheless, existing work on timeline generation often ignores an important factor, the attention attracted to topics of interest ...
Wayne Xin Zhao, Yanwei Guo, Rui Yan 0001, Yulan He 0001, Xiaoming Li 0001   +4 more
openaire   +1 more source

The malfunction of domain-specific attentional process in social anxiety: attentional process of social and non-social stimuli

Cognition and Emotion, 2021
Socially anxious people have a malfunction in attentional systems. However, it is uncertain whether the malfunction of the attentional system is a domain-specific process to social stimuli or a domain-general process to non-social stimuli. Therefore, we investigated the effects of social anxiety on the domain specificity of the attentional process ...
Kenta, Ishikawa, Takato, Oyama, Matia, Okubo   +2 more
openaire   +2 more sources

Neural mechanisms of social attention

Trends in Cognitive Sciences, 2009
Social attention is conveyed primarily by gaze, but also by head and body orientation. These cues not only signal a seen agent's direction of attention but are also used to infer their current goals and intentions. Here, we review recent research showing that different gaze, head and body orientations are represented by distinct neural mechanisms, and ...
Lauri, Nummenmaa, Andrew J, Calder
openaire   +2 more sources