Results 51 to 60 of about 1,091,145 (261)

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Does Social Background Influence Political Science Grades?

Current Issues in Education, 2013
This paper tests a hypothesized linear relationship between social background and final grades in several political science courses that I taught at the University of Central Arkansas.  I employ a cross-sectional research design and ordinary least square
Gizachew Tiruneh
doaj  

Social Responsibility, the Concept and the Cognitive Background [PDF]

Akofena
: The current research paper sheds light on the ’problematic of social responsibility’ in an attempt to study the variety of descriptions related to the concept of “responsibility ‘’ through laying out the concept (frames and dimensions), domains ...
Mokhtaria MOKADDEM & Mohamed DJEBELLA
doaj   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Overcoming Obstacles? Institutional Support for the Pathways to Higher Education at German Vocational Schools

Social Inclusion
The institutionalization of new types of vocational schools in the 1960s and 1970s aimed to open up the German education system and create new pathways for accessing higher education, particularly for socially disadvantaged students.
Nadine Dörffer, Nadine Bernhard
doaj   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

The Social Status Of Female Characters In Chi Li’s Novels 池莉小说中女性的社会地位

Lingua Cultura, 2012
Chi Li is a novelist writing “new realism” novels based on the custom of Wu Han people. Chi Li’s works have different social background according to different period stages.
Mariana Mariana
doaj  

The Social Background of 1 Corinthians 1-4

Perichoresis: The Theological Journal of Emanuel University, 2019
The social structure of the Corinthian ecclesia is a reasonable cause for the dissensions that had occurred between her members. The people from the higher social strata of the church may have sought to advance their honor by desiring to extend their ...
Mihăilă Corin
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source