Results 101 to 110 of about 4,651,306 (251)

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

open access: yesFEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka   +11 more
wiley   +1 more source

Whatever people say I am, that's what I am: Social labeling as a social marketing tool. [PDF]

open access: yes
In this paper, we present a procedure to apply the social labeling technique as a social marketing tool. With four studies, we tested its potential for the promotion of pro-environmental consumer behavior.
Cornelissen, Gert   +2 more
core  

Women\u27s Sexuality and Sexual Orientation: A Sociological Explanation of Behavior [PDF]

open access: yes, 2010
Mis-perceptions and biases surrounding women\u27s sexual health and behavior makes it almost impossible to determine what constructs a women\u27s sexual behavior; social forces or their personal orientation. Social forces may have a stronger influence on
Lawrence, Katie-Ann
core   +2 more sources

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

open access: yesFEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva   +10 more
wiley   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

The Tuning in to Kids parenting program delivered online improves emotion socialization and child behavior in a first randomized controlled trial

open access: yesScientific Reports
Emotion-focused parenting interventions have only rarely been evaluated systematically in Europe. This study investigates the effectiveness of “Tuning in to Kids” (TIK) from Australia delivered online in a randomized controlled trial.
Susan C. A. Burkhardt   +2 more
doaj   +1 more source

From use to abuse: psychological, neurobiological, and spiritual pathways in relational harm and recovery

open access: yesFrontiers in Behavioral Neuroscience
This viewpoint examines the distinction between relational “use” and “abuse” through psychological, neurobiological, relational, and spiritual lenses. It conceptualizes use as a form of mutual and ethical interdependence, whereas abuse is understood as a
Shilpa Bhardwaj   +2 more
doaj   +1 more source

Home - About - Disclaimer - Privacy