Results 161 to 170 of about 16,009,179 (311)

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

open access: yesMolecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura   +19 more
wiley   +1 more source

About prisoners and dictators: the role of other-self focus, social value orientation, and sterotype primes in shaping cooperative behavior. [PDF]

open access: yes
Six experiments examined the effects of person factors (i.e., social value orientation and consistency) and situation factors (i.e., stereotype primes) on cooperative behavior in various experimental games.
Smeesters, D   +4 more
core  

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

open access: yesMolecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober   +16 more
wiley   +1 more source

An exploratory study comparing the social behavior of intersex and female goats. [PDF]

open access: yesFront Vet Sci
Schmitt O   +4 more
europepmc   +1 more source

Impacts of social media on consumer buying behavior

open access: yes, 2017
This research responds to the main question of the impact of social media on consumer purchasing decisions.Understanding consumer behavior is complex.Companies that want to build a strong customer base and develop a successful marketing strategy should ...
Alkhalifah, Zahrah
core  

Estudio Longitudinal Social de Chile 2018

open access: yes
ELSOC has been designed to evaluate how Chileans think, feel, and behave regarding a set of social issues related to conflict and social cohesion in Chile.
Reproducible Research, Centre for Social Conflict and Cohesion Studies COES
core   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

open access: yesMolecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir   +13 more
wiley   +1 more source

Estudio Longitudinal Social de Chile 2019

open access: yes
ELSOC has been designed to evaluate how Chileans think, feel, and behave regarding a set of social issues related to conflict and social cohesion in Chile.
Reproducible Research, Centre for Social Conflict and Cohesion Studies COES
core   +1 more source

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