Results 91 to 100 of about 1,083,246 (301)

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

The Effectiveness of Cognitive-Behavioral Social Skills Training (CBSST) on Reducing Symptoms of Students with Externalizing Behavior Disorders [PDF]

Ravānshināsī-i Afrād-i Istis̠nāyī, 2013
Given the emphasis the specialists put on the necessity of mental health interventions for elementary school children as a primary prevention, and also their focus on the treatment and development of mental health, the present research aims to study the ...
Tayyebeh Yeganeh, Abbasali Hossein-Khanzadeh, Mohammadreza Zarbakhsh   +2 more
doaj  

Potential markers of aggressive behavior: the fear of other persons' laughter and its overlaps with mental disorders.

PLoS ONE, 2012
BackgroundAnecdotal evidence suggested that some outbreaks of aggression and violence may be related to a fear of being laughed at and ridiculed. The present study examined the potential association of the fear of other persons' laughter (gelotophobia ...
Elisabeth M Weiss, Günter Schulter, H Harald Freudenthaler, Ellen Hofer, Natascha Pichler, Ilona Papousek   +5 more
doaj   +1 more source

Impulsivity, Rejection Sensitivity, and Reactions to Stressors in Borderline Personality Disorder

, 2016
This research investigated baseline impulsivity, rejection sensitivity, and reactions to stressors in individuals with borderline personality disorder compared to healthy individuals and those with avoidant personality disorder .
Berenson, Kathy R., Downey, Geraldine, Glaser, Erin, Gregory, Wesley Ellen, Rafaeli, Eshkol, Romirowsky, Aliza, Yang, Xiao   +6 more
core   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Cognitive Rehabilitation of Adaptive Behavior in Children with Neurodevelopmental Disorders: A Meta-Analysis

Occupational Therapy International, 2018
Objectives. Negative behavioral problems often occur following the onset of neurodevelopmental disorders and have an overall impact on the affected children, specifically in terms of their social developmental level.
Si-nae Ahn, Sujin Hwang
doaj   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Explanation of Self-determination Experiences in Students with Externalized Behavior Disorders: A Phenomenological Approach

Journal of Qualitative Research in Health Sciences, 2019
Introduction: Students with externalized behavior disorders have lower levels of capacity for self-determination skills. The aim of this study was to explain self-determination experiences in students with externalized behavior disorders.
Zahra Mansurnejad, Mokhtar Malekpour, Amir Ghamarani   +2 more
doaj  

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Culture and Cognitive Theory: Toward a Reformulation [PDF]

, 2001
In a provocative and important recent article Anthony Marsella (1998) makes an eloquent plea for the forging of a new metadiscipline of psychology that he labels global-community psychology.
Durrant, Russil, Thakker, Jo
core   +1 more source