Results 71 to 80 of about 476,960 (310)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Hippocampal neuroligin-2 overexpression leads to reduced aggression and inhibited novelty reactivity in rats. [PDF]

PLoS ONE, 2013
Disturbances of the excitation/inhibition (E/I) balance in the brain were recently suggested as potential factors underlying disorders like autism and schizophrenia resulting in associated behavioral alterations including changes in social and emotional ...
Christine Kohl, Orbicia Riccio, Jocelyn Grosse, Olivia Zanoletti, Céline Fournier, Mathias V Schmidt, Carmen Sandi   +6 more
doaj   +1 more source

Development of lifetime comorbidity in the world health organization world mental health surveys [PDF]

, 2011
CONTEXT: Although numerous studies have examined the role of latent variables in the structure of comorbidity among mental disorders, none has examined their role in the development of comorbidity.
LEE, Sing, Lepine, J.P., Haro, J.M., Posada-Villa, J., ZASLAVSKY, Alan M., DEMYTTENAERE, Koen, LEPINE, Jean-Pierre, Jean-Pierre Lepine, de Graaf, Ron, Ustun, T.B., Zaslavsky, A.M., de Graaf, R., ALONSO, Jordi, ANDRADE, Laura, GREEN, Jennifer Greif, Matchsinger, H., STEIN, Dan J., Leo J. Russo, Jordi Alonso, Karam, A., KARAM, Aimee, Koen Demyttenaere, Sing Lee, Ustün, T. Bedirhan, Alan M. Zaslavsky, Constanta Mihaescu-Pintia, Maria Petukhova, Herbert Matchsinger, McLaughlin, K.A., HARO, Josep Maria, MIHAESCU-PINTIA, Constanta, Dan J. Stein, GIROLAMO, Giovanni de, RUSSO, Leo J., SAGAR, Rajesh, Sergio Aguilar-Gaxiola, Ron de Graaf, Sagar, R., Ronald C. Kessler, T. Bedirhan Üstün, Russo, L.J., Ormel, J., BENJET, Corina, Demyttenaere, K., Stein, D.J., Katie A. McLaughlin, Johan Ormel, Lee, S., de Girolamo, Giovanni, Corina Benjet, Josep Maria Haro, Petukhova, M., Laura Andrade, HU, Chi Yi, Benjet, C., Jose Posada-Villa, AGUILAR-GAXIOLA, Sergio, FAYYAD, John, Andrade, L., Alonso, J., POSADA-VILLA, Jose, Mihaescu-Pintia, C., Green, J.G., ORMEL, Johan, Hu, C.Y., Aimee Karam, de Girolamo, G., Chi yi Hu, Fayyad, J., Rajesh Sagar, MCLAUGHLIN, Katie A., Aguilar-Gaxiola, S., UESTUEN, T. Bedirhan, KESSLER, Ronald C., PETUKHOVA, Maria, Jennifer Greif Green, Giovanni de Girolamo, Kessler, R.C., MATCHSINGER, Herbert, GRAAF, Ron de, John Fayyad   +80 more
core   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Anterior insular cortex regulation in autism spectrum disorders

Frontiers in Behavioral Neuroscience, 2015
Autism spectrum disorders (ASDs) comprise a heterogeneous set of neurodevelopmental disorders characterized by dramatic impairments of interpersonal behavior, communication, and empathy.
Andrea eCaria, Andrea eCaria, Simona ede Falco   +2 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Behavioural outcomes and psychopathology during adolescence [PDF]

, 2013
Preterm birth is associated with a high risk of residual neurodevelopmental disability and cognitive impairment. These problems are closely associated with psychiatric disorders and thus it is unsurprising that preterm birth also confers high risk for ...
Wolke, Dieter, Johnson, Samantha J.
core   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Social behavior disorders in Alzheimer's disease in social isolation

Fundamental and Clinical Medicine
Aim. To investigate the effect of social isolation on social behavior and levels of psychoemotional markers (oxytocin and vasopressin) in mice with an injection-induced model of Alzheimer’s disease (AD). Materials and Methods. The study was conducted on CD1 male mice aged 3–4 months, which received intrahippocampal injection of either β-amyloid (in ...
E. K. Perova, A. M. Avliyakulyeva, V. E. Tsypunov, T. V. Gorina, O. L. Lopatina   +4 more
openaire   +1 more source