Results 71 to 80 of about 1,083,246 (301)

The Effects of Social Stories on the Social Interaction and Behavior of Students with Autism Spectrum Disorders [PDF]

open access: yes, 2007
Students with disabilities, including those with autism spectrum disorders are increasingly being educated in the general education setting. Professionals working with students with autism spectrum disorders may implement a variety of interventions to ...
Ventimiglia, Alana
core   +1 more source

Neuroenhancement of exposure therapy in anxiety disorders [PDF]

open access: yes, 2015
Although exposure-based treatments and anxiolytic medications are more effective than placebo for treating anxiety disorders, there is still considerable room for further improvement.
Curtiss, Joshua   +2 more
core   +2 more sources

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Anterior insular cortex regulation in autism spectrum disorders

open access: yesFrontiers in Behavioral Neuroscience, 2015
Autism spectrum disorders (ASDs) comprise a heterogeneous set of neurodevelopmental disorders characterized by dramatic impairments of interpersonal behavior, communication, and empathy.
Andrea eCaria   +2 more
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Extreme overvalued beliefs: How violent extremist beliefs become “normalized” [PDF]

open access: yes, 2018
Extreme overvalued beliefs (EOB) are rigidly held, non-deusional beliefs that are the motive behind most acts of terrorism and mass shootings. EOBs are differentiated from delusions and obsessions. The concept of an overvalued idea was first described by
Rahman, Tahir
core   +3 more sources

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Social behavior disorders in Alzheimer's disease in social isolation

open access: yesFundamental and Clinical Medicine
Aim. To investigate the effect of social isolation on social behavior and levels of psychoemotional markers (oxytocin and vasopressin) in mice with an injection-induced model of Alzheimer’s disease (AD). Materials and Methods. The study was conducted on CD1 male mice aged 3–4 months, which received intrahippocampal injection of either β-amyloid (in ...
E. K. Perova   +4 more
openaire   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Does d-cycloserine facilitate the effects of homework compliance on social anxiety symptom reduction? [PDF]

open access: yes, 2018
BACKGROUND: Prior studies examining the effect of d-cycloserine (DCS) on homework compliance and outcome in cognitive-behavior therapy (CBT) have yielded mixed results.
Hofmann, Stefan G.   +8 more
core   +1 more source

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