Results 141 to 150 of about 3,983,391 (348)

ALKBH3 m1A Demethylase Deficiency Reduces Alzheimer's Amyloid‐β Pathology

open access: yesAdvanced Science, EarlyView.
This study identifies that ALKBH3‐driven m1A demethylation orchestrates Alzheimer's disease progression by disrupting mitochondrial and synaptic homeostasis. This epitranscriptomic mechanism suppresses PINK1‐mediated mitophagy via m1A erasure, leading to mitochondrial dysfunction, oxidative stress, elevated Aβ production, and impaired microglial ...
Yueyang Li   +25 more
wiley   +1 more source

NIR‐II Imaging‐Guided Photothermal Activation of a TRPV4‐Targeted Nanoplatform Delivering Cycloastragenol to Promote Microglia Reprogramming and α‐Synuclein Clearance in Parkinson's Disease

open access: yesAdvanced Science, EarlyView.
ABSTRACT Current therapies for Parkinson's disease (PD) fail to concurrently address α‐synuclein (α‐syn) aggregation and microglia‐mediated neuroinflammation. Herein, we engineer a near‐infrared‐II (NIR‐II) phototheranostic nanoplatform, CAG/FD1080@MM‐aTRPV4, for synergistic regulation of microglial function and real‐time monitoring of PD pathology. We
Hsuan Lo   +9 more
wiley   +1 more source

Women's Social Capital and Social Cohesion in Kerala: The Case of Kudumbashree [PDF]

open access: yesJournal of Economic and Social Development (Varaždin)
This paper examines the claim that the Kudumbashree women of Kerala, built around microfinance but now a key actor in Kerala’s economic, social, and welfare landscape, constitute a form of social capital and contributes to social cohesion.
Bhoola   +9 more
doaj  

Are Friendly Farmers Environmentally Friendly? Environmental Awareness as a Social Capital Outcome [PDF]

open access: yes
This paper examines the hypothesis that social capital at the individual level affects environmentally friendly practices. Social capital represents the social connectedness of the individual.
Jordan, Jeffrey L., Munasib, Abdul B.A.
core   +1 more source

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