Results 161 to 170 of about 16,927,067 (395)

Social action/local care [PDF]

, 2010
Swann, David
core   +1 more source

Gut microbiota diversity is prognostic in metastatic hormone receptor‐positive breast cancer patients receiving chemotherapy and immunotherapy

Molecular Oncology, EarlyView.
In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern, Kristian Holm, Nikolai Kragøe Andresen, Andreas Hagen Røssevold, Corinna Bang, Bjørn Naume, Johannes R. Hov, Jon Amund Kyte   +7 more
wiley   +1 more source

Three strong women: from care to university

Scottish Journal of Residential Child Care, 2005
Poor educational 'outcomes' of looked after children have been a matter of increasing concern. This article explores some of the factors that might make for educational success by looking at the experiences of three young women who have been in care in ...
Ian Milligan
doaj   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

A Review of the Healthcare and Social Care Needs of the Older Prisoner Population in England and Wales

Social Sciences
In recent years, research on older prisoners in England and Wales has expanded significantly, and the term “older prisoner” is now well entrenched in the prison-based literature.
Paul Gavin, Cody Normitta Porter, Finley MacDonald   +2 more
doaj   +1 more source

Earliest Cranio-Encephalic Trauma from the Levantine Middle Palaeolithic: 3D Reappraisal of the Qafzeh 11 Skull, Consequences of Pediatric Brain Damage on Individual Life Condition and Social Care

, 2014
Hélène Coqueugniot, Olivier Dutour, B. Arensburg, Henri Duday, Bernard Vandermeersch, Anne-Marie Tillier   +5 more
openalex   +2 more sources

The Characteristics and Social Functioning of Pathological Social Withdrawal, “Hikikomori,” in a Secondary Care Setting: A One-Year Cohort Study [PDF]

, 2020
Hissei Imai, Toko Takamatsu, Hideaki Mitsuya, Hajime Yoshizawa, Hidehiko Mitsuya, Toshi A. Furukawa   +5 more
openalex   +1 more source

The contribution of post-accession Polish migrants to adult social care services [PDF]

, 2011
In an increasingly globalised world, for many people who are using the UK adult social care services, interaction with post accession migrants as paid carers now represents an everyday encounter.
Judd, Dawn Beatrice
core  

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source