Results 41 to 50 of about 15,242,158 (222)

The greening of Oregon's workforce: jobs, wages, and training [PDF]

open access: yes, 2009
"This report was produced at the request of the Oregon Workforce Investment Board"--Page iThis archived document is maintained by the State Library of Oregon as part of the Oregon Documents Depository Program. It is for informational purposes and may not

core  

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

open access: yesFEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang   +2 more
wiley   +1 more source

Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research

open access: yesFEBS Letters, EarlyView.
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley   +1 more source

A three-way partnership: reflections and lessons from co-producing social care research with practitioners, researchers and the public

open access: yesResearch Involvement and Engagement
Background Co-production in social care research seeks to bridge the gap between academic inquiry, frontline practice, and lived experience by actively involving practitioners, researchers, and public members as equal partners throughout the research ...
Julia Greig   +9 more
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

open access: yesMolecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur   +11 more
wiley   +1 more source

Turning the tables: creating space for lived experience leadership in research

open access: yesResearch Involvement and Engagement
This commentary shares reflections and learning about the factors that supported the meaningful involvement of a service user being funded to undertake a service evaluation in a health and social care trust in Northern Ireland and the personal ...
Lisa Tracy Morrison   +4 more
doaj   +1 more source

Predictive and prognostic biomarkers of Bacillus Calmette‐Guérin therapy failure in bladder cancer patients: A systematic review

open access: yesMolecular Oncology, EarlyView.
High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira   +7 more
wiley   +1 more source

The cost-effectiveness of specialist hospital discharge and intermediate care services for patients who are homeless

open access: yesBMC Health Services Research
Background Recognising the diverse healthcare needs of the population, there is a growing emphasis on tailoring hospital discharge processes to address the unique challenges faced by individuals who are homeless, aiming to enhance the efficiency and ...
Michela Tinelli   +14 more
doaj   +1 more source

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

open access: yesMolecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault   +12 more
wiley   +1 more source

Does age matter in the social care workforce?

open access: yesJournal of Long-Term Care, 2018
Context: With the population in England ageing, more people are living with complex physical and mental health needs and need care and support. As a result demand for care workers is increasing.
Valerie Lipman   +2 more
doaj   +3 more sources

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