Results 51 to 60 of about 452,232 (264)

A couple-based HIV prevention intervention for Latino men who have sex with men: study protocol for a randomized controlled trial

Trials, 2018
Background Latino men who have sex with men (MSM) experienced a 13% increase in HIV diagnoses from 2010 to 2014, more than any other racial/ethnic subgroup of MSM in the United States.
Omar Martinez, M. Isabel Fernandez, Elwin Wu, Alex Carballo-Diéguez, Guillermo Prado, Adam Davey, Ethan Levine, Brian Mattera, Nikki Lopez, Omar Valentin, Ashley Murray, Madeline Sutton   +11 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Outbreak of acute renal failure in Panama in 2006: a case-control study

Bulletin of the World Health Organization, 2008
OBJECTIVE: In September 2006, a Panamanian physician reported an unusual number of patients with unexplained acute renal failure frequently accompanied by severe neurological dysfunction. Twelve (57%) of 21 patients had died of the illness.
E Danielle Rentz, Lauren Lewis, Oscar J Mujica, Dana B Barr, Joshua G Schier, Gayanga Weerasekera, Peter Kuklenyik, Michael McGeehin, John Osterloh, Jacob Wamsley, Washington Lum, Camilo Alleyne, Nestor Sosa, Jorge Motta, Carol Rubin   +14 more
doaj  

Implementation and evaluation of a Project ECHO telementoring program for the Namibian HIV workforce

Human Resources for Health, 2020
Background The Namibian Ministry of Health and Social Services (MoHSS) piloted the first HIV Project ECHO (Extension for Community Health Outcomes) in Africa at 10 clinical sites between 2015 and 2016.
Leonard Bikinesi, Gillian O’Bryan, Clay Roscoe, Tadesse Mekonen, Naemi Shoopala, Assegid T. Mengistu, Souleymane Sawadogo, Simon Agolory, Gram Mutandi, Valerie Garises, Rituparna Pati, Laura Tison, Ledor Igboh, Carla Johnson, Evelyn M. Rodriguez, Tedd Ellerbrock, Heather Menzies, Andrew L. Baughman, Laura Brandt, Norbert Forster, John Scott, Brian Wood, Kenton T. Unruh, Sanjeev Arora, Michelle Iandiorio, Summers Kalishman, Sarah Zalud-Cerrato, Jutta Lehmer, Stephen Lee, Mohammed A. Mahdi, Samantha Spedoske, Alexandra Zuber, Brigg Reilley, Christian B. Ramers, Ndapewa Hamunime, Gabrielle O’Malley, Bruce Struminger   +36 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Sexualized drug use, sexual behavior patterns, and internal labor migration among men who have sex with men in Wuhan, China

Discover Public Health
Background Men who have sex with men (MSM) in China bear approximately 23% of new HIV infection in 2020. Sexualized drug use (SDU) is a significant risk factor for HIV.
Jie Ding, Xuejiao Hu, Ji Wang, Weidong Tian, Wei Huang, Fangzhao Ming, Yang Yang, Ming Gao, Ke Hong, Xiaobing Yang, Hui Xie   +10 more
doaj   +1 more source

Effect of Phenobarbital on Chloramphonicol-Induced Toxicity in Rat Liver and Small Intestine [PDF]

Iranian Journal of Basic Medical Sciences, 2013
Objective(s): The aim of the present study is to determine the effect of Chloramphenicol (CAP) on rat liver and small intestine. Effect of phenobarbital (PB) on CAP toxicity was also investigated.
Massumeh Ahmadizadeh, Masood Esmailpoor, Zahra Goodarzi   +2 more
doaj  

An exploratory study of challenges and successes in implementing adapted family-based treatment in a community setting

Journal of Eating Disorders, 2018
Although family-based treatment (FBT) is accepted as the first-line treatment for adolescent anorexia nervosa, studies show that it is infrequently used by clinicians in community settings.
Ellen Astrachan-Fletcher, Erin C. Accurso, Setareh Rossman, Susan F. McClanahan, Gina Dimitropoulos, Daniel Le Grange   +5 more
doaj   +1 more source