A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner
Molecular Oncology, EarlyView.We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp +13 more
wiley +1 more source
Forms of Capital, Social Change and the Weight of the Past: The Effective Agents of the Swiss Field of Power 1910-2015. [PDF]
SociologyRossier T, Lunding JA.
europepmc +1 more source
The Impact of the West and Social Change: International Seminar at Leyden [PDF]
, 1961 openalex +1 more source
Molecular Oncology, EarlyView.C–C chemokine receptor type 9 (CCR9) is an immune checkpoint in pancreatic ductal adenocarcinoma (PDAC). Novel anti‐CCR9 antibody SRB2 was evaluated in combination with cytotoxic chemotherapy in PDAC cells, patient‐derived organoids, patient‐derived xenografts, and humanized mouse models.
Hannah G. McDonald +18 more
wiley +1 more source
Relationships for Social Change: The Value of the Promotora Framework in Navigating Systems of Employment. [PDF]
J Marital Fam TherAbraham D +5 more
europepmc +1 more source
To Change a Nation, Propaganda and Indoctrination in Communist China. By Franklin Houn. Glencoe: The Free Press; East Lansing: Bureau of Social and Political Research, Michigan State University, 1961. x, 250. Table, Appendix, Index. [PDF]
, 1962 John M. H. Lindbeck
openalex +1 more source
Unraveling LINE‐1 retrotransposition in head and neck squamous cell carcinoma
Molecular Oncology, EarlyView.The novel RetroTest method allows the detection of L1 activation in clinical samples with low DNA input, providing global L1 activity and the identification of the L1 source element. We applied RetroTest to a real‐world cohort of HNSCC patients where we reported an early L1 activation, with more than 60% of T1 patients showing L1 activity.
Jenifer Brea‐Iglesias +12 more
wiley +1 more source
Molecular Oncology, EarlyView.Overexpression of CHRDL2 in colon cancer cells makes them more stem‐like and resistant to chemo‐ and radiotherapy. CHRDL2‐high cells have upregulation of the WNT pathway, genes involved in the DNA damage response (DDR) pathway and epithelial‐to‐mesenchymal transition (EMT). This leads to quicker repair of damaged DNA and more cell migration.
Eloise Clarkson, Annabelle Lewis
wiley +1 more source
Dissonance as a productive force in the emergence of alternative crisis support and impetus for social change-principles and organizational form of the association Open Dialogue Leipzig e.V. [PDF]
Front PsycholKlatt T +5 more
europepmc +1 more source