Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
Mothers' Experience of Social Change and Individualistic Parenting Goals Over Two Generations in Urban China. [PDF]
Front Psychol, 2021 Bian Q, Chen Y, Greenfield PM, Yuan Q.
europepmc +1 more source
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
Forms of Capital, Social Change and the Weight of the Past: The Effective Agents of the Swiss Field of Power 1910-2015. [PDF]
SociologyRossier T, Lunding JA.
europepmc +1 more source
Fostering and sustaining transnational solidarities for transformative social change: Advancing community psychology research and action. [PDF]
Am J Community Psychol, 2022 Sonn CC, Fox R, Keast S, Rua M.
europepmc +1 more source
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source
Relationships for Social Change: The Value of the Promotora Framework in Navigating Systems of Employment. [PDF]
J Marital Fam TherAbraham D +5 more
europepmc +1 more source
Does believing in different types of religion affect subjective wellbeing? Analysis of the public data of the Taiwan Social Change Survey. [PDF]
Front Psychol, 2022 Ding Y, Huo W, Jin Y.
europepmc +1 more source
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Social change and relationship quality among sexual minority individuals: Does minority stress still matter? [PDF]
J Marriage Fam, 2022 Frost DM, Fingerhut AW, Meyer IH.
europepmc +1 more source