Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Critical Reflections on Public Health, Policy and Social Change Toward Healthy Societies Comment on "How to Build Healthy Societies: A Thematic Analysis of Relevant Conceptual Frameworks". [PDF]
Int J Health Policy ManagFisher M.
europepmc +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Dissonance as a productive force in the emergence of alternative crisis support and impetus for social change-principles and organizational form of the association Open Dialogue Leipzig e.V. [PDF]
Front PsycholKlatt T +5 more
europepmc +1 more source
"Films for Social Change", New additions and order form
"Films for Social Change", New additions and order ...
core
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Boundary Objects as Dialogical Learning Accelerators for Social Change in Design for Health: Systematic Review. [PDF]
JMIR Hum Factors, 2022 Terlouw G +5 more
europepmc +1 more source
Molecular Oncology, EarlyView.Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen +14 more
wiley +1 more source
Leading a Healthcare Organization During a Period of Social Change: A Qualitative Study of Chief Executive Officers. [PDF]
J Gen Intern MedMeltzer KK +4 more
europepmc +1 more source