Results 211 to 220 of about 1,299,510 (268)

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

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Social Statistics and Social Change

Journal of the Australian Population Association, 1987
Although it is customary to regard the statistical product of modern nation-states as being composed of two broad categories, social statistics and economic statistics, this paper emphasizes the links rather than the dividing lines between statistical programmes. It traces the attempts of three statistician economists to classify and quantify “national
openaire   +2 more sources

The measurement of social change

Papers presented at the the March 3-5, 1959, western joint computer conference on XX - IRE-AIEE-ACM '59 (Western), 1959
Is it possible to build a synoptic instrument, similar to a telescope or a radar network, for viewing one's own society? How may we interpret the myriads of social activities that are presently undertaken? Preliminary explorations suggest that we need sensing techniques, or transducers, that pick up changes going on inside the society.
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LONELINESS AND SOCIAL CHANGE

American Journal of Psychiatry, 1955
Rapprochement between psychiatry and sociology has developed rapidly during the last few years. In theory and in research there is more collaboration than ever before and every prospect that this interdisciplinary trend will continue for some time to come. The present discussion is a case in point. It lies in the emerging field of social psychiatry (or
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What Are Social Change Makers and Social Change Organisations?

2023
This chapter develops the core concepts of the book – social change makers (SCM) and social change organisations (SCO). The first part of the chapter focuses on the SCMs and explains that a biographical perspective is needed to understand their involvement in SCOs.
Silke Roth, Clare Saunders
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Social Service or Social Change?

2017
I first began thinking about this issue when the Oakland Men’s Project was established in 1979. At that time, we were responding to women in the domestic violence, sexual assault prevention, and child sexual assault prevention movements. When asked what we could do as men they said that they had their hands full dealing with the survivors of male ...
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