Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
Social Change and the Health of Sexual Minority Individuals: Do the Effects of Minority Stress and Community Connectedness Vary by Age Cohort? [PDF]
Arch Sex Behav, 2022 Frost DM +6 more
europepmc +1 more source
VALUES OF PROFESSIONAL ACTIVITY OF FUTURE TEACHERS IN CHANGING SOCIAL AND POLITICAL CONDITIONS
, 2019 Tetyana Pantiuk +2 more
openalex +1 more source
Managed Care and Changes in Health Care Delivery in the United States: Implications for Social Work Practice in Health Care Settings [PDF]
, 2016 Shabu Abraham Varghese
openalex +1 more source
Engaged Scholarship Methods for Positive Social Change [PDF]
, 2017 Villanueva, George
core +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Organized Leadership for Equitable Change: Union-active Teachers Dedicated to Social Justice
, 2011 Cynthia Rottmann
openalex +1 more source
Effect of chemotherapy on passenger mutations in metastatic colorectal cancer
Molecular Oncology, EarlyView.Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui +6 more
wiley +1 more source
Gamo's cultural forum-Dubussha as a tool for social change communication: Illiteracy and child labor abuse as a case in point. [PDF]
HeliyonAyalew MT, Walea Wanke T.
europepmc +1 more source