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TTT and R2TP chaperone complexes are required for the assembly and activation of mTORC1. WAC directly interacts with components of TTT, R2TP, and mTORC1, and these interactions are affected by the availability of glucose and glutamine, correlating with changes in mTORC1 activity.
Sofía Cabezudo+11 more
wiley +1 more source
Nitric oxide‐forming nitrite reductases in the anaerobic ammonium oxidizer Kuenenia stuttgartiensis
Anammox bacteria remove fixed nitrogen from their environment via anaerobic ammonium oxidation (anammox) with nitrite as electron acceptor and dinitrogen gas as product. The first anammox step is the conversion of nitrite to nitric oxide by nitrite reductase.
Femke J. Vermeir+4 more
wiley +1 more source
Two‐way inhibition of PAX5 transcriptional activity by PAX5::CBFA2T3
PAX5::CBFA2T3 (PAX5‐C) is a fusion protein of the B‐cell transcription factor, PAX5, and is found in B‐cell ALL. We propose a putative model of two‐way inhibition of PAX5 transcriptional activity by PAX5‐C. There are two ways of repression by PAX5‐C: DNA‐binding‐dependent way and HDAC‐dependent way, with either being sufficient for the repression. HDAC
Reina Ueno+12 more
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Ro 31‐8220 suppresses bladder cancer progression via enhancing autophagy in vitro and in vivo
The pan‐protein kinase C inhibitor Ro‐31‐8220 demonstrates potent anti‐bladder cancer effects both in vitro and in vivo by suppressing migration/invasion, inducing apoptosis and crucially activating autophagy, where blocking autophagy with chloroquine reduces its cell‐killing efficacy, suggesting its promise as a novel therapeutic candidate requiring ...
Shengjun Fu+12 more
wiley +1 more source
In this research, a rat model of asthma was created using OVA, and polydatin served as an intervention. By inhibiting ferroautophagy mediated by NCOA4 and averting ferroptosis, polydatin has been demonstrated to reduce asthma. This work presents new ideas for investigating the mechanism of polydatin's ability to alleviate asthma, in addition to ...
Wei Li+5 more
wiley +1 more source
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Industry, Innovation and Infrastructure, 2021
Social change describes the transformations of a society in terms of values systems, social organization, and practices. What may appear a radical idea at one moment in history can become a taken-for-granted norm at another. Woman’s suffrage, civil rights, and environmental concern are all powerful twentieth-century examples of this.
Brady Wagoner, S. Power
semanticscholar +5 more sources
Social change describes the transformations of a society in terms of values systems, social organization, and practices. What may appear a radical idea at one moment in history can become a taken-for-granted norm at another. Woman’s suffrage, civil rights, and environmental concern are all powerful twentieth-century examples of this.
Brady Wagoner, S. Power
semanticscholar +5 more sources
, 1992
Approaches to discourse analysis Michel Foucault and the analysis of discourse a social theory of discourse intertextuality text analysis - constructing social relations and "the self", constructing social reality discourse and social change in ...
N. Fairclough
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Approaches to discourse analysis Michel Foucault and the analysis of discourse a social theory of discourse intertextuality text analysis - constructing social relations and "the self", constructing social reality discourse and social change in ...
N. Fairclough
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Social Change and Crime Rate Trends: A Routine Activity Approach
, 1979In this paper we present a "routine activity approach" for analyzing crime rate trends and cycles. Rather than emphasizing the characteristics of offenders, with this approach we concentrate upon the circumstances in which they carry out predatory ...
Lawrence E. Cohen, M. Felson
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Social Change in a Material World
, 2019Social Change in a Material World offers a new, practice theoretical account of social change and its explanation. Extending the author’s earlier account of social life, and drawing on general ideas about events, processes, and change, the book ...
T. Schatzki
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