Results 51 to 60 of about 20,716,741 (337)

Making tau amyloid models in vitro: a crucial and underestimated challenge

open access: yesFEBS Letters, EarlyView.
This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley   +1 more source

Linking Social Entrepreneurship and Social Change: The Mediating Role of Empowerment

open access: yes, 2016
Entrepreneurship is increasingly considered to be integral to development; however, social and cultural norms impact on the extent to which women in developing countries engage with, and accrue the benefits of, entrepreneurial activity.
H. Haugh, A. Talwar
semanticscholar   +1 more source

Interaction vesicles as emerging mediators of host‐pathogen molecular crosstalk and their implications for infection dynamics

open access: yesFEBS Letters, EarlyView.
Interaction extracellular vesicles (iEVs) are hybrid vesicles formed through host‐pathogen communication. They facilitate immune evasion, transfer pathogens' molecules, increase host cell uptake, and enhance virulence. This Perspective article illustrates the multifunctional roles of iEVs and highlights their emerging relevance in infection dynamics ...
Bruna Sabatke   +2 more
wiley   +1 more source

Greener cement sector and potential climate strategy development between 2015-2030 (Hungarian case study)

open access: yesApstract: Applied Studies in Agribusiness and Commerce, 2015
Advancing the domestic industrial production towards a sustainable, resource-preserving direction can become an important pillar to support competitiveness in the European Union, as well as in Hungary.
Mária Böröcz   +3 more
doaj   +1 more source

Decoding the dual role of autophagy in cancer through transcriptional and epigenetic regulation

open access: yesFEBS Letters, EarlyView.
Transcriptional and epigenetic regulation controls autophagy, which exerts context‐dependent effects on cancer: Autophagy suppresses tumorigenesis by maintaining cellular homeostasis or promotes tumor progression by supporting survival under stress. In this “In a Nutshell” article, we explore the intricate mechanisms of the dual function of autophagy ...
Young Suk Yu, Ik Soo Kim, Sung Hee Baek
wiley   +1 more source

Locating Leadership and Political Will in Social Policy: The Story of India’s MGNREGA

open access: yesPolitics and Governance, 2020
The term ‘political will’ is often conveniently used to explain the success or failure of any policy or programme. It has emerged as the “sine qua non of policy success which is never defined except by its absence” (Hammergren, 1998, p. 12). Therefore, a
Ujjwal Krishna, Chris Roche
doaj   +1 more source

Transformational responses to climate change: beyond a systems perspective of social change in mitigation and adaptation

open access: yes, 2016
There is a growing imperative for responses to climate change to go beyond incremental adjustments, aiming instead for society‐wide transformation. In this context, sociotechnical (ST) transitions and social–ecological (SE) resilience are two prominent ...
R. Gillard   +3 more
semanticscholar   +1 more source

A stepwise emergence of evolution in the RNA world

open access: yesFEBS Letters, EarlyView.
How did biological evolution emerge from chemical reactions? This perspective proposes a gradual scenario of self‐organization among RNA molecules, where catalytic feedback on random mixtures plays the central role. Short oligomers cross‐ligate, and self‐assembly enables heritable variations. An event of template‐externalization marks the transition to
Philippe Nghe
wiley   +1 more source

Dental Pathology, Wear, and Diet in a Hunting and Gathering Forest-Dwelling Group: The Batak People of Palawan Island, The Philippines

open access: yesDental Anthropology, 2006
Described are observations on Batak foods, tooth use, oral hygiene, and resulting wear and oral pathology in dental casts of 29 Batak ranging from 15 to 49 years of age. Commonly consumed foods are roughly 80 percent plant, and 20 percent animal products.
Christy G. Turner II, James F. Eder
doaj   +1 more source

B cell mechanobiology in health and disease: emerging techniques and insights into therapeutic responses

open access: yesFEBS Letters, EarlyView.
B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro   +2 more
wiley   +1 more source

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