Results 71 to 80 of about 1,880,904 (318)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Social Change and Women's Health

open access: yesInternational Journal of Health Services, 2013
Over the past five decades, the organization of women's lives has changed dramatically. Throughout the industrialized world, paid work and family biographies have been altered as the once-dominant role of homemaker has given way to the role of secondary, dual, or even primary wage-earner.
McDonough P, Worts D, McMunn A, Sacker A
openaire   +2 more sources

Mapping the new field of Communication for Development and Social Change

open access: yes, 2005
All those involved in the analysis and application of Communication for Development and Social Change - or what can broadly be termed "development communication" - would probably agree that in essence communication for social change is the sharing of ...
Servaes, J.E.J., Servaes, Jan
core  

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Listening to micro-business operators: what are their social and educational needs?

open access: yes, 2004
This paper discusses issues that had been revealed during 15 in-depth interviews and a subsequent questionnaire survey of 91 micro-business (five or fewer employees) operators in Hamilton, New Zealand.
Samujh, Helen
core  

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Youth democracy and social change

open access: yes, 2006
In this paper I examine youth as participants in social change. A particular focus\ud is youth participation through voting. Currently there is much concern worldwide\ud that young people are disengaging from democratic participation through voting,\ud ...
Edwards, Kathy
core  

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Financialisation, media and social change [PDF]

open access: yesNew Political Economy, 2016
This article uses a circuit of communication framework to examine the role of the media in shaping public debate on the financial system and the way in which this impacts on audience response and related societal impacts. It is founded in debates about neo-liberalism and financialisation which highlight the shift of power from, or through, the state to
openaire   +3 more sources

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

open access: yesFEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes   +4 more
wiley   +1 more source

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