Results 91 to 100 of about 7,119,137 (303)

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Empowering newcomers? Power asymmetries and negotiations between newly arrived migrants and volunteers within buddy programmes

International Journal of Evidence Based Coaching and Mentoring
Research on buddy programmes for newly arrived migrants focuses predominantly on integration outcomes. However, the intervention is also prone to reproducing power imbalances.
Gaëlle Mortier, Stijn Oosterlynck, Peter Raeymaeckers   +2 more
doaj   +1 more source

Growth and Diversification of Horticulture Crops in Karnataka

SAGE Open, 2014
With the growth of technology, modernization, and changes in food habits, agricultural cropping pattern of the country has undergone a major shift in the recent past, moving away from the cereal to non-cereal crops cultivation, especially toward the ...
Komol Singha, Rohi Choudhary, Kedar Vishnu   +2 more
doaj   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Social Change and the Family [PDF]

This paper explores the social change of the past 40 years through reporting the results of a restudy. It argues that social change can be understood, culturally, as involving a process of de-institutionalisation and, structurally, as involving ...
Charlotte Davies, Chris Harris, Nickie Charles   +2 more
core  

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Beyond the backyard: Scaling up of resistance to wind power in Sweden

Environmental Challenges
Since 2009, when a municipal veto right was established, wind power in Sweden has become intensely politicised and questioned. Having been considered the key technology to drive the energy system transition by all parliamentary parties before 2010, the ...
Simon Haikola, Jonas Anshelm, Johan Niskanen   +2 more
doaj   +1 more source

Blogs as Elusive Ethnographic Texts

International Journal of Qualitative Methods, 2017
Burgeoning online environments offer completely new opportunities for ethnographic and other forms of qualitative research. Yet there are no clear standards for how we study online texts from an ethnographic perspective.
Liza C. Kurtz, Sarah Trainer, Melissa Beresford, Amber Wutich, Alexandra Brewis   +4 more
doaj   +1 more source