Results 111 to 120 of about 7,119,137 (303)

From Distribution to Audience Engagement: Social Change Through Film [PDF]

, 2010
What comes to mind when someone mentions independent film "distribution"? You can probably define that fairly easily – the selling and delivery of these titles to audiences through any number of means: theatrical, DVD sales, festival release, broadcast ...
Emily Verellen
core  

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

A new species of the mud terrapin Pelusios offers insights into early hominin habitats at the Pliocene Hadar Formation of Ethiopia

Scientific Reports
A novel extinct species of mud terrapin Pelusios awashi sp. nov. is described from the Hadar Formation in Ethiopia. Referred specimens include articulated and isolated specimens from multiple individuals that represent most elements of the shell and a ...
Brent Adrian, Christopher J. Campisano, Kaye E. Reed, Denise F. Su   +3 more
doaj   +1 more source

We Can Build a New Tomorrow - Competencies for Transformative Spatial Planning in Swedish Municipalities

European Journal of Spatial Development
This article highlights the urgent need to explore how transformative planning can be put into practice and what competencies urban and regional planners need to facilitate this transition.
Dick Magnusson, Kristina Trygg, Ida Grundel, Sabrina Fredin   +3 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Catalyzing social change: Does concentration encourage action? [PDF]

PLoS One, 2022
Berger J, Jackson JC, Kolsarici C.
europepmc   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Access to surgery in Ecuador using the enhanced 2-step floating catchment area approach

BMC Global and Public Health
Background Traditional surgical access metrics are often presented at the national level, providing poor insight for local policy makers. The Enhanced Two-Step Floating Catchment Area (E2SFCA) method is an alternative to current methods with two key ...
Taylor Wurdeman, Alejandro Torres Balarezo, Alfredo Borrero Vega, Tanujit Dey, Maria Falconi, Maria José Garcia, Mateo Iza, Nikathan Kumar, Ayla Gerk, Zachary Fowler, Edgar Rodas, Juan Carlos Salamea, Sabrina Juran, John G. Meara, Tarsicio Uribe-Leitz   +14 more
doaj   +1 more source