Results 131 to 140 of about 40,371,065 (348)

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

A new species of the mud terrapin Pelusios offers insights into early hominin habitats at the Pliocene Hadar Formation of Ethiopia

Scientific Reports
A novel extinct species of mud terrapin Pelusios awashi sp. nov. is described from the Hadar Formation in Ethiopia. Referred specimens include articulated and isolated specimens from multiple individuals that represent most elements of the shell and a ...
Brent Adrian, Christopher J. Campisano, Kaye E. Reed, Denise F. Su   +3 more
doaj   +1 more source

We Can Build a New Tomorrow - Competencies for Transformative Spatial Planning in Swedish Municipalities

European Journal of Spatial Development
This article highlights the urgent need to explore how transformative planning can be put into practice and what competencies urban and regional planners need to facilitate this transition.
Dick Magnusson, Kristina Trygg, Ida Grundel, Sabrina Fredin   +3 more
doaj   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Health and social impacts of climate change

, 2020
Climate change poses a major threat to society, human health and health inequities. The health and social impacts of climate change are becoming clearer. There is a general consensus that climate change will negatively affect health and social wellbeing.
Friel, Sharon, Bowen, Kathryn
core  

Social change marketing in the age of direct benefit marketing – where to from here? [PDF]

, 2005
Social change marketing is at the crossroads. With the American Marketing Association's decision to revise the definition of marketing to include direct benefit to the organisation, one of the central tenets of social marketing is in conflict with the ...
Dann, Stephen M.
core  

Cryptocurrencies for social change

, 2019
Fil: Porcherot, Raphael. Institutions et Dynamiques Historiques de la Société et de l’Economie (IDHE.S); France.
Orzi, Ricardo, Porcherot, Raphael, Valdecantos, Sebastián   +2 more
openaire   +3 more sources

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source