Results 151 to 160 of about 7,119,137 (303)

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Health and Human Wellbeing in China: Do Environmental Issues and Social Change Matter? [PDF]

Front Psychol, 2022
Zhao W, Chang M, Yu L, Sohail MT.
europepmc   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Social change at the local level: A psychobiography of Khali Sweeney from Detroit's downtown boxing gym. [PDF]

J Pers, 2023
Case AS, Aguiñiga SM, Hoxsey A.
europepmc   +1 more source

Cultural Tradition and Social Change in Agriculture [PDF]

, 1990
Bausinger H., Bendix R., Breuer M., Brock D., Bruuggemann B., Bultena G., Deenen, Eisenstadt S. N., Elwert G., Flora P., Hildenbrand B., Hoselitz B. F., Inhetveen H., Kolsch O., Kotter H., Kotter H., Meyer-Mansour D., Murdock S. H., Pitt D. C., Pongraiz H., Pongratz H., Priebe H., Reimann H., Rosenbaum H., Salamon S., Shanin T., Spittler G., Touraine A., Weber M., Weippert G., Wurzbacher G., Ziche J.   +31 more
core   +1 more source

Demographic Change, Social Security Systems, and Savings [PDF]

In theory, improvements in healthy life expectancy should generate increases in the average age of retirement, with little effect on savings rates. In many countries, however, retirement incentives in social security programs prevent retirement ages from
David Canning, David E. Bloom, Michael Moore, Rick Mansfield   +3 more
core  

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Culture and Social Change in Mothers' and Fathers' Individualism, Collectivism and Parenting Attitudes. [PDF]

Soc Sci, 2021
Lansford JE, Zietz S, Al-Hassan SM, Bacchini D, Bornstein MH, Chang L, Deater-Deckard K, Di Giunta L, Dodge KA, Gurdal S, Liu Q, Long Q, Oburu P, Pastorelli C, Skinner AT, Sorbring E, Tapanya S, Steinberg L, Uribe Tirado LM, Yotanyamaneewong S, Alampay LP.   +20 more
europepmc   +1 more source