Results 91 to 100 of about 517,196 (309)

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Improving support and planning ahead for older people with learning disabilities and family carers: a mixed-methods study

Health and Social Care Delivery Research
Background People with learning disabilities are living longer. Despite government policy to encourage people to lead supported lives in their community, family carers often maintain support due to dissatisfaction with services.
Sara Ryan, Louise Wallace, Elizabeth Tilley, Irene Tuffrey-Wijne, Magdalena Mikulak, Rebecca Anderson, Angeli Vaid, Pam Bebbington, Richard Keagan-Bull, Emmie Morrissey, Angela Martin   +10 more
doaj   +1 more source

Reconceptualising Well-being: Social Work, Economics and Choice

Culture Unbound: Journal of Current Cultural Research, 2014
In this paper we examine the intersection of well-being, agency and the current political and economic structures which impact on social work with adults and in doing so contribute to ‘interpreting and mapping out the force fields of meaning production' (
Graeme Simpson, Ani Murr
doaj   +1 more source

The Impact of Corporate Social Responsibility on the Choice of R and D or Marketing: Evidence from the Chinese Listed Firms

, 2020
Ran Jiao, Subin Wen
openalex   +1 more source

Social Ranking Problems at the Interplay between Social Choice Theory and Coalitional Games [PDF]

, 2023
Felix Fritz, Stefano Moretti, Jochen Staudacher   +2 more
openalex   +1 more source

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

Parameterized Algorithmics for Computational Social Choice: Nine\n Research Challenges [PDF]

, 2014
Robert Bredereck, Jiehua Chen, Piotr Faliszewski, Jiong Guo, Rolf Niedermeier, Gerhard J. Woeginger   +5 more
openalex   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source