Results 91 to 100 of about 14,394,948 (360)
FEBS Letters, EarlyView.PARP‐1 is a key enzyme in the DNA damage response, and its inhibition induces cancer cell death via synthetic lethality. Au(I)‐based drugs, such as aurothioglucose and sodium aurothiomalate, block PARP‐1's DNA‐dependent activity by targeting its zinc finger domains.
Uliana Bashtanova, Melinda Jane Duer
wiley +1 more source
The role of histone modifications in transcription regulation upon DNA damage
FEBS Letters, EarlyView.This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley +1 more source
Domínios de Lingu@gem, 2019 In this essay, I investigate (socio)linguistic scholarship on African continuities in Brazilian Portuguese to analyze the semiotic ideologies that inform academic literature on this topic.
Marcus Vinicius Avelar
doaj +1 more source
Social class mobility in modern Britain: changing structure, constant process
, 2016 The class structure provides an important context for the study of social mobility. The evolution of the class structure is the all-important factor determining individuals’ changing experience of mobility, as expressed in absolute rates.
J. Goldthorpe
semanticscholar +1 more source
Household wealth and adolescents' social-emotional functioning in schools. [PDF]
, 2019 This study attempts a two-part shift in educational research narrowly fixated on the socioeconomic determinants of student test-score performance. First, we focus on variations in how to measure wealth. Second, we move beyond achievement and focus on the
Gottfried, Michael A, Ream, Robert K
core +1 more source
The limits of social class in explaining ethnic gaps in educational attainment [PDF]
, 2011 This paper reports an analysis of the educational attainment and progress between age 11 and age 14 of over 14,500 students from the nationally representative Longitudinal Study of Young People in England (LSYPE).
Abbott D. +21 more
core +1 more source
Molecular Oncology, EarlyView.Integrating ancestry, differential methylation analysis, and machine learning, we identified robust epigenetic signature genes (ESGs) and Core‐ESGs in Black and White women with endometrial cancer. Core‐ESGs (namely APOBEC1 and PLEKHG5) methylation levels were significantly associated with survival, with tumors from high African ancestry (THA) showing ...
Huma Asif, J. Julie Kim
wiley +1 more source
Molecular Oncology, EarlyView.There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes +20 more
wiley +1 more source
Missing Class: Strengthening Social Movement Groups By Seeing Class Cultures [PDF]
, 2014 [Excerpt] At heart, this book is a comparison, not of twenty-five groups, but of the four major class categories I found among 362 meeting participants.
Leondar-Wright, Betsy
core +1 more source
Couples’ places of meeting in late 20th century Britain: class, continuity and change [PDF]
, 2007 This article examines couples’ places or contexts of meeting in the second half of the 20th century in Great Britain, utilizing a typology developed by Bozon and Héran.
Lampard, Richard
core +1 more source