Results 101 to 110 of about 14,054,010 (381)

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

FEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan, Lu Qi, Pierre Zalloua   +2 more
wiley   +1 more source

Quem é Classe Média no Brasil? Um Estudo sobre Identidades de Classe*

Dados: Revista de Ciências Sociais
Este artigo busca contribuir para o debate atual sobre a classe média no Brasil, tendo como foco as identidades de classe e percepções dos brasileiros sobre a classe média. Na última década milhares de indivíduos atingiram níveis intermediários de renda,
André Ricardo Salata
doaj   +1 more source

The anabolic steroid stanozolol is a potent inhibitor of human MutT homolog 1

FEBS Letters, EarlyView.
MutT homolog 1 (MTH1) is a member of the NUDIX superfamily of enzymes and is an anticancer drug target. We show that stanozolol (Stz), an anabolic steroid, is an unexpected nanomolar inhibitor of MTH1. The X‐ray crystal structure of the human MTH1–Stz complex reveals a unique binding scaffold that could be utilized for future inhibitor development ...
Emma Scaletti Hutchinson, Robert Gustafsson Westergren, Ingrid Almlöf, Ann‐Sofie Jemth, Martin Scobie, Ulrika Warpman Berglund, Thomas Helleday, Pål Stenmark   +7 more
wiley   +1 more source

L’embourgeoisement, moteur du changement social en banlieue populaire au tournant du XXIe siècle

Métropoles
Since deindustrialisation, the question of social change in working-class suburbs has been the subject of a wealth of sociological literature. Following recent French research dealing with the spatial dimension of inequalities, this article proposes a ...
Pauline Clech
doaj   +1 more source

Between race and class

Domínios de Lingu@gem, 2019
In this essay, I investigate (socio)linguistic scholarship on African continuities in Brazilian Portuguese to analyze the semiotic ideologies that inform academic literature on this topic.
Marcus Vinicius Avelar
doaj   +1 more source

Mycobacterium tuberculosis sulfurtransferase SseA is activated by its neighboring gene product Rv3284

FEBS Letters, EarlyView.
Tuberculosis remains a global health challenge and new therapeutic targets are required. Here, we characterized SseA, a sulfurtransferase from Mycobacterium tuberculosis involved in macrophage infection, and its interaction with the newly identified protein SufEMtb that activates SseA enzymatic activity.
Giulia Di Napoli, Alex Fissore, Edoardo Salladini, Eleonora Raccuia, Simonetta Oliaro‐Bosso, Alessia Ruggiero, Rita Berisio, Milagros Medina, Adrian Velazquez‐Campoy, Salvatore Adinolfi, Mauro Marengo   +10 more
wiley   +1 more source

Archaeal protein containing domain of unknown function 2193 undergoes oligomeric reconfiguration upon iron–sulfur cluster binding

FEBS Letters, EarlyView.
This work presents the characterization of MvoDUF2193, a Methanococcus voltae (Mvo) protein from the domain of unknown function (DUF) 2193 family. We demonstrate that MvoDUF2193 binds a single [4Fe–4S] cluster per subunit and that cluster occupancy regulates the transition from an apo tetramer to a [4Fe–4S] monomeric form. This structural transition is
Emily M. Dieter, James Larson, Monika Tokmina‐Lukaszewska, Jin Xiong, Jared Green, Yisong Guo, William E. Broderick, Brian Bothner, Joan B. Broderick   +8 more
wiley   +1 more source

Forskyvninger i skolestart: Hvilken rolle spiller kjønn og sosial bakgrunn?

Søkelys på Arbeidslivet, 2017
Regelen i norsk skole er at barn begynner på skolen det kalenderåret de fyller 6 år. Vi ser på mønsteret i utsatt og fremskutt skolestart etter kjønn og foreldrenes utdanning.
Sara Cools, Pål Schøne, Marte Strøm
doaj   +1 more source

The limits of social class in explaining ethnic gaps in educational attainment [PDF]

, 2011
This paper reports an analysis of the educational attainment and progress between age 11 and age 14 of over 14,500 students from the nationally representative Longitudinal Study of Young People in England (LSYPE).
Abbott D., Caplan C., Coleman J. S., Cook P. J., DES, DfES, Fryer R. G., Gillborn D., Hedges L. V., Kenway P., KewalRamani A., Modood T., Phillips M., Powdthavee N., Sewell T., Sirin S. R., Steve Strand, Strand S., Swann Report, Sylva K., US Census Bureau, Wilson D.   +21 more
core   +1 more source

Mechanisms and kinetic assays of aminoacyl‐tRNA synthetases

FEBS Letters, EarlyView.
Igor Zivkovic, Morana Dulic, Ita Gruic‐Sovulj   +2 more
wiley   +1 more source