Results 121 to 130 of about 2,297,329 (297)
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
A Systematic Review of the Effects of AI-Assisted Moderation on Individuals and Groups
Human-Machine Communication JournalThis review paper provides a conceptualization of AI-assisted content moderation with various degrees of autonomy and summarizes experimental evidence for how different levels of automation in content moderation and related losses of autonomy affect ...
Zehui Yu +3 more
doaj +1 more source
, 2013 A theory of change is a purposeful model of how an initiative— such as a policy, a strategy, a program, or a project—contributes through a chain of early and intermediate outcomes to the intended result. Theories of change help navigate the complexity of
Serrat, Olivier
core +1 more source
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
Rearing group size in young ravens: stress load or social opportunity?
Royal Society Open ScienceUnderstanding how variations in early social environments generate different experiences for offspring (affecting their behaviour and the way others behave towards them) is crucial for uncovering mechanisms underlying the development of social behaviour.
Palmyre H. Boucherie +3 more
doaj +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Organized social complexity as an analytical problem - An introduction and explication [PDF]
Systems analysis of organized social complexity in terms of independent ...
La Porte, T. R.
core +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Social complexity, life-history and lineage influence the molecular basis of castes in vespid wasps. [PDF]
Nat Commun, 2023 Wyatt CDR +8 more
europepmc +1 more source