Results 171 to 180 of about 21,610,538 (392)

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Psychosocial determinants of oral health outcomes in young children

Frontiers in Pediatrics
ObjectiveTo examine the social determinants of early childhood caries (ECC), one of the greatest public health risks affecting children, and examine alternative pathways of influence.MethodsA physically healthy, socio-demographically high-risk sample of ...
Dorota T. Kopycka-Kedzierawski, Patricia G. Ragusa, Changyong Feng, Kim Flint, Gene E. Watson, Cynthia L. Wong, Steven R. Gill, Ronald J. Billings, Thomas G. O’Connor   +8 more
doaj   +1 more source

Natural variation in social conditions affects male mate choosiness in the amphipod Gammarus roeselii. [PDF]

Curr Zool, 2022
Lipkowski K, Steigerwald S, Schulte LM, Sommer-Trembo C, Jourdan J.   +4 more
europepmc   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

Representações sociais sobre famílias em situação de vulnerabilidade: uma revisão da literatura [Social representations of families in vulnerable conditions: a literature review]

Revista Enfermagem UERJ, 2015
A família é influenciada por fatores de ordem social, cultural, econômica, política, determinando transformações em sua configuração e dinâmica.
Joana Iabrudi Carinhanha, Lucia Helena Garcia Penna, Denize Cristina de Oliveira   +2 more
doaj  

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

Lifestyles: from the individual to the context

Revista Facultad Nacional de Salud Pública, 2012
Lifestyles have been studied by different disciplines such associology, anthropology, and epidemiology. Both the termand the greatest developments in this regard stem from thesocial and cultural sciences, which consider lifestyles as groupbehavior ...
Luz S. Álvarez C.
doaj  

Personal attitudes, perceived social norms, and health-risk behavior among female adolescents with chronic medical conditions

, 2013
Jennifer Kunz, Rachel Neff Greenley, Kathleen Mussatto, Betsy Roth-Wojcicki, Tami Miller, Mary Ellen Freeman, Sarah J. Lerand   +6 more
openalex   +1 more source

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

Molecular Oncology, EarlyView.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian, Sriraam Sivachandran, Melissa Galati, Brandon Ramchatesingh, Hibo Rijal, Johnny Hanna, Elena Netchiporouk, May Chergui, Margaret Redpath, Samy Abou Setah, Ivan V. Litvinov   +10 more
wiley   +1 more source