Results 181 to 190 of about 6,200,273 (303)

Mechanistic modeling of social conditions in disease-prediction simulations via copulas and probabilistic graphical models: HIV case study. [PDF]

Health Care Manag Sci
Khosheghbal A, Haas PJ, Gopalappa C.
europepmc   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Indicadores de saúde materno infantil em Belo Horizonte, Minas Gerais, Brasil, 2001: análise dos diferenciais intra-urbanos

Cadernos de Saúde Pública
A análise espacial de indicadores de saúde tem sido um importante instrumento na detecção de diferenciais intra-urbanos. O estudo objetivou traçar um perfil dos nascimentos em Belo Horizonte, Minas Gerais, Brasil, em 2001, analisando a presença de ...
Amélia Augusta de Lima Friche, Waleska Teixeira Caiaffa, Cibele Comini César, Lúcia Maria de Figueiredo Goulart, Maria Cristina de Mattos Almeida   +4 more
doaj  

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Differences in self-rated health among older adults according to socioeconomic circumstances: the Bambuí Health and Aging Study

Cadernos de Saúde Pública
Self-rated health is influenced by socioeconomic circumstances, but related differences in its structure have received little attention. The objective of this study was to examine whether self-rated health structure differs according to socioeconomic ...
Maria Fernanda Lima-Costa, Josélia Oliveira Araújo Firmo, Elizabeth Uchôa   +2 more
doaj  

Genetically identical mice express alternative reproductive tactics depending on social conditions in the field. [PDF]

Proc Biol Sci
Zipple MN, Vogt CC, Sheehan MJ.
europepmc   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Desigualdade social e outros determinantes da altura em crianças: uma análise multinível

Cadernos de Saúde Pública
Estudo transversal de base populacional sobre altura de crianças de 12 a 59 meses (n = 2.632) foi realizado em Porto Alegre, Brasil. Usou-se regressão linear multinível para investigar o efeito de condições sócio-econômicas, demográficas, de saúde e dos ...
Maria de Lourdes Drachler, Márcia Christina Stark Andersson, José Carlos de Carvalho Leite, Tom Marshall, Denise Rangel Ganzo de Castro Aerts, Paulo Fontoura Freitas, Elsa Regina Justo Giuglianni   +6 more
doaj  

Can you be a peer if you don't share the same health or social conditions? A qualitative study on peer integration in a primary care setting. [PDF]

BMC Prim Care
Lessard É, O'Brien N, Panaite AC, Leclaire M, Castonguay G, Rouly G, Boivin A.   +6 more
europepmc   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source