Results 201 to 210 of about 19,192,322 (351)

Social Stability Relates Social Conditions to the Syndemic of Sex, Drugs, and Violence. [PDF]

open access: yesJ Urban Health, 2020
Moen M   +5 more
europepmc   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau   +8 more
wiley   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

open access: yesMolecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan   +16 more
wiley   +1 more source

Early life social conditions and adverse experiences are associated with childhood BMI and perceived overeating. [PDF]

open access: yesPediatr Obes
Bartoskova Polcrova A   +5 more
europepmc   +1 more source

Conditions and conditioning factors of social innovation

open access: yesArbor: Ciencia, Pensamiento y Cultura, 2011
The concept of innovation has conditions and specifications that limit its’ space of action. The most important conditions are those related to social change, the limits of social structures in knowledge societies, the limits in the culture of some social groups and the relations between diverse situations, their praxis and the rethoric that sometimos ...
openaire   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

open access: yesMolecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain   +10 more
wiley   +1 more source

Screening for adverse social conditions in child healthcare settings: protocol for a systematic review. [PDF]

open access: yesBMJ Open
Schwenker R   +6 more
europepmc   +1 more source

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