Results 171 to 180 of about 20,042,590 (303)

Permanent census tracts, Toledo, Ohio, 1937

These maps of the permanent census tracts of Toledo, Ohio, were published in 1937. Designed by the Toledo City Plan Commission and approved by the United States Census Bureau and the Toledo Council of Social Agencies, it shows the ten large census ...
The Toledo City Plan Commission
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Middle managers in Scotland’s social services: A scoping analysis for the Scottish Social Services Council by University of Stirling

, 2014
In this report we start by setting the context for our scoping analysis of the role and functions of middle managers in Scotland's social services. Within this section, we discuss the challenge of identifying ‘who is a middle manager' and whether ...
Patterson, Frances, George, Carol
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Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Mechanistic modeling of social conditions in disease-prediction simulations via copulas and probabilistic graphical models: HIV case study. [PDF]

Health Care Manag Sci
Khosheghbal A, Haas PJ, Gopalappa C.
europepmc   +1 more source

Higher prevalence of depressed mood in immigrants' offspring reflects their social conditions in the host country: The HELIUS study. [PDF]

PLoS One, 2020
Stronks K, Şekercan A, Snijder M, Lok A, Verhoeff AP, Kunst AE, Galenkamp H.   +6 more
europepmc   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

SOCIAL WORK: Putting together the broken pieces of our lives

, 2018
The journal has an eclectic mix of articles, but all offer the opportunity to reflect on the varied aspects of social work ...
Browne, Frank, Irish Association of Social Workers   +1 more
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Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Dominant personal values and stress-coping strategies in relation to health and social conditions of kinship foster carers aged 60+ providing care for their biological grandchildren. [PDF]

BMC Geriatr
Giezek M, Landowski M, Zabielska P, Karakiewicz B.   +3 more
europepmc   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source