Results 171 to 180 of about 6,200,273 (303)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

Fatores de risco para sobrepeso em crianças no Sul do Brasil

open access: yesCadernos de Saúde Pública
Estudo transversal de base populacional investigou determinantes de sobrepeso em crianças de 12 a 59 meses em Porto Alegre (n = 2.660). Razões de chance (RC) de sobrepeso, definido por peso/altura > 2 escores-z do padrão NCHS, foram estimadas para ...
Maria de Lourdes Drachler   +5 more
doaj  

Conditions and conditioning factors of social innovation

open access: yesArbor: Ciencia, Pensamiento y Cultura, 2011
The concept of innovation has conditions and specifications that limit its’ space of action. The most important conditions are those related to social change, the limits of social structures in knowledge societies, the limits in the culture of some social groups and the relations between diverse situations, their praxis and the rethoric that sometimos ...
openaire   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch   +13 more
wiley   +1 more source

Pobreza e HIV/AIDS: aspectos antropológicos e sociológicos

open access: yesCadernos de Saúde Pública
A partir da perspectiva das várias epidemias de HIV/AIDS que coexistem em mesmo espaço, bem como dos dados epidemiológicos do Brasil, acredita-se serem observáveis as variações já descritas alhures - feminilização, pauperização, juvenilização e ...
Richard Parker   +1 more
doaj  

Home - About - Disclaimer - Privacy