Results 121 to 130 of about 11,902,515 (281)
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Study on the Evaluation of Integrated Benefit of Land Consolidation Based on Ameliorate Fuzzy AHP
Shuitu baochi yanjiu, 2012 This paper took a land consolidation project in Yongquan Town,Wuxiang Country,Shanxi Province as an example,the expert consultation method and AHP method were applied to construct evaluation indicator system of the land consolidation comprehensive ...
LIU Lin1 +5 more
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Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Explaining Variations in Patterns of Fiscal Consolidation [PDF]
The comparative study of debt and fiscal consolidation has acquired a new focus with the re-emergence of debt as a major problem consequent upon the global financial crisis.
Niamh Hardiman +1 more
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Colombia Internacional, 2006 In the 1990s, the theoretical and political debate focused on the role of social movements in democratic consolidation. This article seeks to analyze if social movements reached a better political insertion that resulted beneficial for the consolidation ...
Julie Masal.
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Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Bringing Domestic Preferences Back Into the Budget: The Politics of Fiscal Consolidation in Italy (1992-1998) [PDF]
, 2002 This paper argues that the content of Italy’s fiscal consolidation in the 1990s has been largely influenced by domestic socio-political coalitions. Namely, the preference over either spending cuts or revenue increases, at the macrolevel, and more so, at ...
Marzinotto, Benedicta
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MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
The Effects of School Board Consolidation and Financing on Student Performance [PDF]
Over the last 20 years, states and provinces have become increasingly involved in the financing and administration of elementary and secondary education.
A. Abigail Payne, Steve Chan, John Leach
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