Results 141 to 150 of about 3,227,851 (305)

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

The social construction of genomics and genetic analysis in ocular diseases in Ibadan, South-western Nigeria. [PDF]

PLoS One, 2022
Olawoye O, Salami KK, Azeez A, Adebola P, Sarimiye T, Imaledo J, Realini T, Hauser MA, Ashaye A.   +8 more
europepmc   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Identity Selection and the Social Construction of Birthdays. [PDF]

Front Psychol, 2021
Pelham BW, DeHart T, Shimizu M, Hardin CD, Han HA, von Hippel W.   +5 more
europepmc   +1 more source

Urban public space and the construction of social life: a social-pedagogical perspective [PDF]

, 2012
Arendt H., Baacke D., Baum W.K., Biesta G., Boomkens R., Bourdieu P., Bouw C., Burke C., Chawla L., Corsaro W.A., Coussée F., Coussée F., De Visscher S., De Visscher S., De Visscher S., De Winter M., Delanty G., Gehl J., Giesecke H., Griet Verschelden, Hiemstra R., Hogan D., Howard E., Hämäläinen J., James A., Kampmann J., Katz C., Lepofsky J., Low S., Lynch K., Lynch K., Mantell W., Maria Bouverne-De Bie, Massey D., Matthews H., McKendrick J., Mitchell D., Nic Gabhainn S., Pink W.T., Portelli A., Prosser J., Rasmussen K., Rasmussen K., Raymund J.F., Schugurensky D., Sennett R., Sven De Visscher, Thompson P., Wildemeersch D., Wridt P.J.   +49 more
core   +1 more source

'How to feel safe': international students study migration [PDF]

, 2012
A variety of institutional and representational mechanisms are used in the construction of 'international students' and other 'migrants' or 'ethnic minorities' as two distinctive social categories. As part of these construction processes, the individuals
Shachar, Itamar
core  

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Diversity in Alzheimer's disease drug trials: Reflections on reporting and social construction of race. [PDF]

Alzheimers Dement, 2022
Babulal GM, Franzen S, Abner EL, Smith JE, van den Berg E, Mindt MR, van Bruchem-Visser RL, Schneider LS, Prins ND, Papma JM.   +9 more
europepmc   +1 more source

Constructing the cultural repertoire in a natural disaster: The role of social media in the Thailand flood of 2011 [PDF]

, 2014
In 2011, Thailand witnessed its worst flooding catastrophe in half a century. In this study, we explored social media as a new and promising weapon to address the physical and morale challenges caused by the natural disaster.
Hackney, R, Kaewkitipong, L, Mao, M, Pan, SL, Ractham, P   +4 more
core   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source