Results 141 to 150 of about 309,699 (265)
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Evaluation of functional performance in commercial buildings
, 2004 This report fully summarises a project designed to enhance commercial real estate performance within both operational and investment contexts through the development of a model aimed at supporting improved decision-making.
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Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Social construction in context
, 1992 Der Verfasser würdigt die Bedeutung des Buchs "The Social Construction of Reality" von Berger und Luckmann anlässlich des 25. Jahrestags seines Erscheinens. Er betont vor allem die Bedeutung, die das Buch als Wegbereiter des symbolischen Interaktionismus, der Soziolinguistik, der Ethnomethodologie und des "interpretativen Paradigmas" generell hatte ...
openaire +3 more sources
A process-social perspective for understanding design information flow [PDF]
, 2017 Question: How can we better understand the impacts of lean practices and BIM-based design on the flow of design information? Purpose: The purpose of this paper is to present a formerly unexplored perspective that integrates both the process, i.e., flow ...
Al Hattab, Malak, Hamzeh, Farook R.
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Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
TERRITORY AS A SOCIAL CONSTRUCTION
História, Ciências, Saúde-Manguinhos, 2023 Renato da Gama-Rosa Costa +1 more
openaire +3 more sources
, 2005 This project aims to assess the extent of economic sustainability of working in international markets by Australian construction design-related firms.
London , Kerry
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Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi +14 more
wiley +1 more source