Results 61 to 70 of about 233,334 (261)
Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions
FEBS Letters, EarlyView.We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva +10 more
wiley +1 more source
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
VertigO, 2016 Using a constructivist political ecology perspective, this exploratory qualitative research examines the social representations, attitudes and impacts that exist in relation to the phenomenon of cyanobacteria.
Karine Dubé +3 more
doaj +1 more source
PICALM::MLLT10 translocated leukemia
FEBS Letters, EarlyView.This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen +7 more
wiley +1 more source
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
Pioneer organization in Samara: from incident to sign
Вестник Самарского университета: История, педагогика, филологияThe article, based on previously unpublished archival sources, examines the process of organizing the first pioneer detachments in Samara, as well as their activities in 1922–1923 using the comparative historical method and microhistorical approach ...
O. A. Titova
doaj +1 more source
Organizations and Markets in Emerging Economies, 2017 This study examines institutional definitions and meanings Ukrainian managers attach to one of the most popular management concepts – the Balanced Scorecard. Socially constructed discourses, that is, beliefs, understandings, expectations, interpretations,
Svitlana Firsova
doaj +1 more source
FEBS Letters, EarlyView.Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson +7 more
wiley +1 more source
Valeurs et normes sociales dans le projet d'émancipation de Cornelius Castoriadis
Labyrinth: An International Journal for Philosophy, Value Theory and Sociocultural Hermeneutics, 2019 The purpose of this article is to analyze the philosophy of values developed by Cornelius Castoriadis from his theory of the imaginary institution of societies. By understanding the emergence of imaginary significations, it is possible to identify their
Christophe Premat
doaj
Social constructions of successful ageing: the case of Ruware Park in Marondera, Zimbabwe
Social Work/Maatskaplike Werk, 2019 Social constructions of successful ageing provide an invaluable resource for challenging and reconfiguring approaches and models of geriatric care. This paper has established that contrary to normative framing of successful ageing as that (ageing) which ...
Mbulayi, Shingirai Paul +1 more
doaj +1 more source