Results 31 to 40 of about 12,577,905 (258)

Deontic logic and adaptive algorithms: The relevance of explicit benefit in versions of the selection task

open access: yesFilosofia Unisinos, 2013
Social contract theory argues that to properly execute thematic versions of the selection task one has to specify, in the rules of such versions, an explicit benefit that can only be achieved in exchange for meeting a requirement.
Miguel López Astorga
doaj   +1 more source

Labor markets for health supply chain management in Rwanda: a qualitative study of stakeholder perspectives

open access: yesBMC Health Services Research, 2023
Background Effective supply chains for health products require an adequate, skilled workforce for supply chain management (SCM). Rwanda faces challenges in human resources for SCM, including limited capacity for SCM at different levels.
Erin Meier   +5 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

open access: yesFEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Neutrality and the Social Contract

open access: yesLes Ateliers de l’Ethique, 2009
Given the fact of moral disagreement, theories of state neutrality which rely on moral premises will have limited application, in that they will fail to motivate anyone who rejects the moral premises on which they are based.
Ian J. Carroll
doaj   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

open access: yesMolecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez   +5 more
wiley   +1 more source

Redrawing state-society boundaries: Egypt's dynamic social contract [PDF]

open access: yes, 2001
Most LDC regimes, especially those with a colonial past, suffer from a deficit in legitimacy. Basing their rule on the personality and achievements of one person, these regimes have failed to pass on their legitimacy to their successors, or sometimes ...
Kamel, Maggie Samir, Kamel, M.S.
core  

KDAC6 alters cell morphology and motility through positive and negative modulation of F‐actin distribution

open access: yesFEBS Open Bio, EarlyView.
KDAC6 has been associated with cell motility and actin structures, but specific domain contributions are not established. The two catalytic domains have differential effects on motility and F‐actin regulation, affecting cortical F‐actin density, motility, stress fibers, and cell spreading.
Taylor V. Joseph   +7 more
wiley   +1 more source

Building Walls, Social Groups and Empires: A Study of Political Power and Compliance in the Neo-Assyrian Period

open access: yesAsia Anteriore Antica, 2023
This contribution aims to use social history and social theory to investigate political power and compliance with authority in ancient Western Asia, through the case study of Neo-Assyrian imperial building projects.
Marta Lorenzon, Caroline Wallis
doaj   +1 more source

Structural studies and functional engineering of NanX: an anhydro‐sialic acid transporter from Escherichia coli

open access: yesFEBS Open Bio, EarlyView.
Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty   +13 more
wiley   +1 more source

Adenosine triphosphate as a modulator of protein interactions and stability

open access: yesFEBS Open Bio, EarlyView.
ATP is best known as the cell's energy currency, but it also shapes how proteins fold, interact, aggregate and form biomolecular condensates. This review explains the emerging physical principles behind these effects, including weak binding to charged protein regions, magnesium‐dependent behaviour and concentration‐dependent control of protein ...
Shuyuan Tan, Robin Curtis
wiley   +1 more source

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